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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CHFR
All Species:
1.82
Human Site:
S218
Identified Species:
4.44
UniProt:
Q96EP1
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.44
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96EP1
NP_001154816.1
664
73386
S218
G
G
I
S
P
K
G
S
G
P
S
V
A
S
D
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001083796
668
74184
K220
G
D
G
G
I
S
P
K
G
C
G
P
S
V
A
Dog
Lupus familis
XP_848636
649
71949
P218
I
S
P
K
E
C
G
P
S
V
A
S
D
E
I
Cat
Felis silvestris
Mouse
Mus musculus
Q810L3
664
73853
R218
T
S
I
S
P
K
G
R
S
S
L
V
A
N
G
Rat
Rattus norvegicus
NP_001009258
663
73935
C218
I
S
I
S
P
K
E
C
S
S
L
V
A
N
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_415086
610
68316
R204
N
A
E
L
G
S
Q
R
T
E
E
E
E
V
L
Frog
Xenopus laevis
Q5FWP4
625
70000
K207
A
I
R
A
S
I
P
K
S
N
L
S
T
Q
E
Zebra Danio
Brachydanio rerio
A5WW08
637
71712
T211
S
S
G
S
P
A
Q
T
R
L
K
W
T
C
W
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_799043
604
66879
G208
L
V
D
D
H
I
K
G
T
A
E
A
I
D
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_175188
466
53085
S98
A
V
D
I
I
S
G
S
E
I
V
P
G
P
E
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
90.5
81.7
N.A.
82.2
81.9
N.A.
N.A.
69.1
66.2
53.6
N.A.
N.A.
N.A.
N.A.
26.3
Protein Similarity:
100
N.A.
92.9
87.1
N.A.
88.5
88.2
N.A.
N.A.
77.5
76
68.6
N.A.
N.A.
N.A.
N.A.
44.1
P-Site Identity:
100
N.A.
13.3
6.6
N.A.
46.6
40
N.A.
N.A.
0
0
13.3
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
N.A.
20
13.3
N.A.
53.3
46.6
N.A.
N.A.
0
13.3
20
N.A.
N.A.
N.A.
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.5
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
32.6
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
20
10
0
10
0
10
0
0
0
10
10
10
30
0
10
% A
% Cys:
0
0
0
0
0
10
0
10
0
10
0
0
0
10
0
% C
% Asp:
0
10
20
10
0
0
0
0
0
0
0
0
10
10
20
% D
% Glu:
0
0
10
0
10
0
10
0
10
10
20
10
10
10
20
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
20
10
20
10
10
0
40
10
20
0
10
0
10
0
20
% G
% His:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
20
10
30
10
20
20
0
0
0
10
0
0
10
0
10
% I
% Lys:
0
0
0
10
0
30
10
20
0
0
10
0
0
0
0
% K
% Leu:
10
0
0
10
0
0
0
0
0
10
30
0
0
0
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
10
0
0
0
0
0
0
0
0
10
0
0
0
20
0
% N
% Pro:
0
0
10
0
40
0
20
10
0
10
0
20
0
10
0
% P
% Gln:
0
0
0
0
0
0
20
0
0
0
0
0
0
10
0
% Q
% Arg:
0
0
10
0
0
0
0
20
10
0
0
0
0
0
0
% R
% Ser:
10
40
0
40
10
30
0
20
40
20
10
20
10
10
0
% S
% Thr:
10
0
0
0
0
0
0
10
20
0
0
0
20
0
0
% T
% Val:
0
20
0
0
0
0
0
0
0
10
10
30
0
20
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
10
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _