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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MOCOS All Species: 18.18
Human Site: S246 Identified Species: 30.77
UniProt: Q96EN8 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96EN8 NP_060417.2 888 98153 S246 A A S Y V S T S P L D L S A H
Chimpanzee Pan troglodytes XP_512097 888 98083 S246 A A S Y V S T S P L D L S A H
Rhesus Macaque Macaca mulatta XP_001105941 857 94684 S248 A A S Y V S T S P L D L S A H
Dog Lupus familis XP_547604 858 94451 G246 L S F Y K L F G F P T G L G A
Cat Felis silvestris
Mouse Mus musculus Q14CH1 862 94994 S246 A A S Y V S T S P L D L S A H
Rat Rattus norvegicus NP_001101895 698 76459 G124 V A P L L R K G Y F G G G T A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506730 921 102647 S263 A A S Y V S T S P L D L T S H
Chicken Gallus gallus XP_419048 810 90102 P236 A G E D F Y F P K K S I A E R
Frog Xenopus laevis
Zebra Danio Brachydanio rerio A2VD33 831 92380 L246 C F V S C S P L D L S Q Y P A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VRA2 781 88085 K207 L W S S L G E K K K N M H N D
Honey Bee Apis mellifera XP_394734 768 86407 C194 L F V Y S A Q C N F S G L K Y
Nematode Worm Caenorhab. elegans Q21657 709 79704 E135 N S I S C V N E E S I L E H E
Sea Urchin Strong. purpuratus XP_001202774 797 88490 I223 C D A D F V T I S F Y K M F G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9C5X8 819 91784 D245 K R W M V L I D A A K G C A T
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 90.8 77.5 N.A. 73.9 60.1 N.A. 62.7 56.3 N.A. 49.8 N.A. 37.7 38.8 30 40.8
Protein Similarity: 100 99.3 93.1 84.1 N.A. 82.2 67.4 N.A. 74.2 69.3 N.A. 66.6 N.A. 56 58.5 48.8 57.7
P-Site Identity: 100 100 100 6.6 N.A. 100 6.6 N.A. 86.6 6.6 N.A. 13.3 N.A. 6.6 6.6 6.6 6.6
P-Site Similarity: 100 100 100 13.3 N.A. 100 13.3 N.A. 100 20 N.A. 13.3 N.A. 26.6 20 13.3 13.3
Percent
Protein Identity: N.A. N.A. N.A. 35.3 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 54.2 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 43 43 8 0 0 8 0 0 8 8 0 0 8 36 22 % A
% Cys: 15 0 0 0 15 0 0 8 0 0 0 0 8 0 0 % C
% Asp: 0 8 0 15 0 0 0 8 8 0 36 0 0 0 8 % D
% Glu: 0 0 8 0 0 0 8 8 8 0 0 0 8 8 8 % E
% Phe: 0 15 8 0 15 0 15 0 8 22 0 0 0 8 0 % F
% Gly: 0 8 0 0 0 8 0 15 0 0 8 29 8 8 8 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 8 8 36 % H
% Ile: 0 0 8 0 0 0 8 8 0 0 8 8 0 0 0 % I
% Lys: 8 0 0 0 8 0 8 8 15 15 8 8 0 8 0 % K
% Leu: 22 0 0 8 15 15 0 8 0 43 0 43 15 0 0 % L
% Met: 0 0 0 8 0 0 0 0 0 0 0 8 8 0 0 % M
% Asn: 8 0 0 0 0 0 8 0 8 0 8 0 0 8 0 % N
% Pro: 0 0 8 0 0 0 8 8 36 8 0 0 0 8 0 % P
% Gln: 0 0 0 0 0 0 8 0 0 0 0 8 0 0 0 % Q
% Arg: 0 8 0 0 0 8 0 0 0 0 0 0 0 0 8 % R
% Ser: 0 15 43 22 8 43 0 36 8 8 22 0 29 8 0 % S
% Thr: 0 0 0 0 0 0 43 0 0 0 8 0 8 8 8 % T
% Val: 8 0 15 0 43 15 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 8 8 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 50 0 8 0 0 8 0 8 0 8 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _