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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SEH1L
All Species:
15.45
Human Site:
S259
Identified Species:
30.91
UniProt:
Q96EE3
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96EE3
NP_001013455.1
360
39649
S259
P
V
R
K
E
L
T
S
S
G
G
P
T
K
F
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_860726
360
39739
S259
P
V
R
K
E
L
T
S
S
G
G
P
T
K
F
Cat
Felis silvestris
Mouse
Mus musculus
Q8R2U0
360
39756
S259
P
L
R
K
E
L
T
S
S
G
G
P
T
K
F
Rat
Rattus norvegicus
Q5XFW8
322
35529
P222
V
R
D
V
A
W
A
P
S
I
G
L
P
T
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516945
324
35581
G224
R
K
E
L
T
S
S
G
G
P
T
K
F
E
I
Chicken
Gallus gallus
Frog
Xenopus laevis
Q4FZW5
360
39707
S259
P
L
R
K
E
L
S
S
S
G
G
V
T
K
F
Zebra Danio
Brachydanio rerio
Q6TGU2
364
39798
N259
P
L
R
R
E
S
A
N
S
S
G
P
T
K
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_610343
354
39496
D254
V
N
L
R
G
V
T
D
A
T
D
I
S
K
L
Honey Bee
Apis mellifera
XP_396810
408
45120
S259
P
T
L
D
S
A
Q
S
G
S
S
R
F
E
I
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781224
444
49387
T259
R
D
Q
F
V
G
S
T
R
I
E
I
R
Q
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53011
349
39104
L249
I
F
K
I
T
E
K
L
S
P
L
A
S
E
E
Red Bread Mold
Neurospora crassa
Q7RZF5
304
33367
L204
P
A
T
N
G
Y
K
L
E
R
E
P
L
A
G
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
98
N.A.
96.1
29.7
N.A.
86.3
N.A.
90.8
81.8
N.A.
53
58.5
N.A.
57.4
Protein Similarity:
100
N.A.
N.A.
99.1
N.A.
98
48.3
N.A.
87.7
N.A.
95.5
89
N.A.
70.5
72.3
N.A.
66.6
P-Site Identity:
100
N.A.
N.A.
100
N.A.
93.3
13.3
N.A.
0
N.A.
80
60
N.A.
13.3
13.3
N.A.
0
P-Site Similarity:
100
N.A.
N.A.
100
N.A.
100
13.3
N.A.
13.3
N.A.
93.3
80
N.A.
40
20
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
27.5
26.1
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
46.3
43.3
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
13.3
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
0
9
9
17
0
9
0
0
9
0
9
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
9
9
9
0
0
0
9
0
0
9
0
0
0
0
% D
% Glu:
0
0
9
0
42
9
0
0
9
0
17
0
0
25
9
% E
% Phe:
0
9
0
9
0
0
0
0
0
0
0
0
17
0
42
% F
% Gly:
0
0
0
0
17
9
0
9
17
34
50
0
0
0
9
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
9
0
0
9
0
0
0
0
0
17
0
17
0
0
17
% I
% Lys:
0
9
9
34
0
0
17
0
0
0
0
9
0
50
0
% K
% Leu:
0
25
17
9
0
34
0
17
0
0
9
9
9
0
9
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
9
0
9
0
0
0
9
0
0
0
0
0
0
0
% N
% Pro:
59
0
0
0
0
0
0
9
0
17
0
42
9
0
0
% P
% Gln:
0
0
9
0
0
0
9
0
0
0
0
0
0
9
0
% Q
% Arg:
17
9
42
17
0
0
0
0
9
9
0
9
9
0
0
% R
% Ser:
0
0
0
0
9
17
25
42
59
17
9
0
17
0
9
% S
% Thr:
0
9
9
0
17
0
34
9
0
9
9
0
42
9
0
% T
% Val:
17
17
0
9
9
9
0
0
0
0
0
9
0
0
0
% V
% Trp:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _