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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIRT1
All Species:
21.52
Human Site:
S684
Identified Species:
39.44
UniProt:
Q96EB6
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96EB6
NP_001135970.1
747
81681
S684
S
G
T
C
Q
S
P
S
L
E
E
P
M
E
D
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001087854
741
80936
S678
S
G
T
C
Q
S
P
S
L
E
E
P
M
E
D
Dog
Lupus familis
XP_546130
745
81496
S682
S
G
T
C
Q
S
P
S
L
E
E
H
L
E
D
Cat
Felis silvestris
Mouse
Mus musculus
Q923E4
737
80353
S674
S
G
T
C
Q
S
P
S
L
E
E
P
L
E
D
Rat
Rattus norvegicus
Q5RJQ4
350
39301
A293
D
C
D
Q
G
C
L
A
L
A
D
L
L
G
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508324
480
51688
S423
E
E
P
L
E
D
E
S
E
I
E
E
F
Y
N
Chicken
Gallus gallus
NP_001004767
756
82614
S696
S
G
S
C
H
S
Q
S
L
D
V
E
D
E
S
Frog
Xenopus laevis
NP_001091195
710
78684
S646
S
S
S
C
G
T
N
S
D
S
E
S
L
L
S
Zebra Danio
Brachydanio rerio
Q7ZVK3
379
42296
D322
V
A
H
L
S
T
C
D
D
G
C
M
T
L
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477351
823
91818
N720
R
H
S
D
L
F
G
N
V
G
H
N
Y
K
D
Honey Bee
Apis mellifera
XP_395386
868
98678
S762
D
S
D
S
D
S
S
S
I
D
E
E
E
D
D
Nematode Worm
Caenorhab. elegans
Q21921
607
68747
Q550
N
A
D
S
E
A
N
Q
L
S
R
A
Q
S
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53685
503
57684
F446
D
M
V
T
H
A
E
F
D
L
N
L
L
G
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
93.3
91.4
N.A.
85.1
23.4
N.A.
49.7
68.1
57.9
22.2
N.A.
37.2
39.9
31.3
N.A.
Protein Similarity:
100
N.A.
95.5
94.3
N.A.
90
33.3
N.A.
54.7
75.4
69.3
35
N.A.
52.2
55.9
47.5
N.A.
P-Site Identity:
100
N.A.
100
86.6
N.A.
93.3
6.6
N.A.
13.3
46.6
26.6
0
N.A.
6.6
26.6
6.6
N.A.
P-Site Similarity:
100
N.A.
100
93.3
N.A.
100
26.6
N.A.
26.6
60
46.6
6.6
N.A.
33.3
46.6
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
22.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
35.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
16
0
0
0
16
0
8
0
8
0
8
0
0
8
% A
% Cys:
0
8
0
47
0
8
8
0
0
0
8
0
0
0
0
% C
% Asp:
24
0
24
8
8
8
0
8
24
16
8
0
8
8
47
% D
% Glu:
8
8
0
0
16
0
16
0
8
31
54
24
8
39
0
% E
% Phe:
0
0
0
0
0
8
0
8
0
0
0
0
8
0
8
% F
% Gly:
0
39
0
0
16
0
8
0
0
16
0
0
0
16
0
% G
% His:
0
8
8
0
16
0
0
0
0
0
8
8
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
8
8
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% K
% Leu:
0
0
0
16
8
0
8
0
54
8
0
16
39
16
8
% L
% Met:
0
8
0
0
0
0
0
0
0
0
0
8
16
0
0
% M
% Asn:
8
0
0
0
0
0
16
8
0
0
8
8
0
0
8
% N
% Pro:
0
0
8
0
0
0
31
0
0
0
0
24
0
0
0
% P
% Gln:
0
0
0
8
31
0
8
8
0
0
0
0
8
0
0
% Q
% Arg:
8
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% R
% Ser:
47
16
24
16
8
47
8
62
0
16
0
8
0
8
16
% S
% Thr:
0
0
31
8
0
16
0
0
0
0
0
0
8
0
0
% T
% Val:
8
0
8
0
0
0
0
0
8
0
8
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
8
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _