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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ATG4C All Species: 11.82
Human Site: T280 Identified Species: 18.57
UniProt: Q96DT6 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96DT6 NP_116241.2 458 52497 T280 D K Q S A S M T S D N A D D K
Chimpanzee Pan troglodytes XP_001159697 366 41520 V195 D H E M R N E V Y H R K I I S
Rhesus Macaque Macaca mulatta XP_001086218 458 52551 T280 D K Q S A S M T S D N A D D K
Dog Lupus familis XP_852273 458 52523 A280 D K Q C T S M A S D N T D D K
Cat Felis silvestris
Mouse Mus musculus Q811C2 458 52068 T280 D K Q T D S V T A G D A R D K
Rat Rattus norvegicus NP_001101418 458 52091 T280 D K Q T D S V T A G D A R D K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514370 459 52127 D280 D K L R A S T D S G K T D D K
Chicken Gallus gallus Q6PZ02 393 44512 L222 K L S L W K P L V L L I P L R
Frog Xenopus laevis Q5XH30 450 51749 N276 D L Q C N K G N E K A V V I L
Zebra Danio Brachydanio rerio Q6DG88 394 44435 P223 E E T A L W K P L V L L I P L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_650452 668 74736 P424 D Q C S I P E P A P K P H V P
Honey Bee Apis mellifera XP_393739 477 54008 G297 N V C Q T S D G K W K S L I L
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786847 723 81931 R537 D L T S L P V R T D P W C A V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8S929 467 51510 E279 V S G S E D G E R G G A P I L
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q7S3X7 506 55337 A333 E D S F M A V A N P D G R G F
Conservation
Percent
Protein Identity: 100 79.9 98.2 94.5 N.A. 90.3 89.5 N.A. 83.2 28.1 68.1 26.8 N.A. 26.5 30.3 N.A. 28
Protein Similarity: 100 79.9 98.9 97.3 N.A. 95.6 95.4 N.A. 88 42.5 82.7 46 N.A. 42 46.3 N.A. 41.4
P-Site Identity: 100 6.6 100 73.3 N.A. 53.3 53.3 N.A. 53.3 0 13.3 0 N.A. 13.3 6.6 N.A. 20
P-Site Similarity: 100 20 100 73.3 N.A. 80 80 N.A. 53.3 6.6 13.3 20 N.A. 26.6 20 N.A. 33.3
Percent
Protein Identity: N.A. N.A. N.A. 22.7 N.A. 21.5
Protein Similarity: N.A. N.A. N.A. 41.1 N.A. 39.3
P-Site Identity: N.A. N.A. N.A. 13.3 N.A. 0
P-Site Similarity: N.A. N.A. N.A. 13.3 N.A. 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 7 20 7 0 14 20 0 7 34 0 7 0 % A
% Cys: 0 0 14 14 0 0 0 0 0 0 0 0 7 0 0 % C
% Asp: 67 7 0 0 14 7 7 7 0 27 20 0 27 40 0 % D
% Glu: 14 7 7 0 7 0 14 7 7 0 0 0 0 0 0 % E
% Phe: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 7 % F
% Gly: 0 0 7 0 0 0 14 7 0 27 7 7 0 7 0 % G
% His: 0 7 0 0 0 0 0 0 0 7 0 0 7 0 0 % H
% Ile: 0 0 0 0 7 0 0 0 0 0 0 7 14 27 0 % I
% Lys: 7 40 0 0 0 14 7 0 7 7 20 7 0 0 40 % K
% Leu: 0 20 7 7 14 0 0 7 7 7 14 7 7 7 27 % L
% Met: 0 0 0 7 7 0 20 0 0 0 0 0 0 0 0 % M
% Asn: 7 0 0 0 7 7 0 7 7 0 20 0 0 0 0 % N
% Pro: 0 0 0 0 0 14 7 14 0 14 7 7 14 7 7 % P
% Gln: 0 7 40 7 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 7 7 0 0 7 7 0 7 0 20 0 7 % R
% Ser: 0 7 14 34 0 47 0 0 27 0 0 7 0 0 7 % S
% Thr: 0 0 14 14 14 0 7 27 7 0 0 14 0 0 0 % T
% Val: 7 7 0 0 0 0 27 7 7 7 0 7 7 7 7 % V
% Trp: 0 0 0 0 7 7 0 0 0 7 0 7 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _