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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ATG4C All Species: 27.27
Human Site: S409 Identified Species: 42.86
UniProt: Q96DT6 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96DT6 NP_116241.2 458 52497 S409 T K M L K F S S K E K Y P L F
Chimpanzee Pan troglodytes XP_001159697 366 41520 Y318 K G I L S L E Y C V G I I G G
Rhesus Macaque Macaca mulatta XP_001086218 458 52551 S409 T K M L K F S S K E K Y P L F
Dog Lupus familis XP_852273 458 52523 S409 T K M L K I S S K E K Y P L F
Cat Felis silvestris
Mouse Mus musculus Q811C2 458 52068 S409 T K M L K I S S K E K Y P L F
Rat Rattus norvegicus NP_001101418 458 52091 S409 T K M L K I S S K E K Y P L F
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514370 459 52127 S409 T K V L K A S S K E K Y P L F
Chicken Gallus gallus Q6PZ02 393 44512 A345 K L S L V R G A L P M F E L V
Frog Xenopus laevis Q5XH30 450 51749 T400 T K V L K S S T K Q N Y P L F
Zebra Danio Brachydanio rerio Q6DG88 394 44435 G346 R K V S N C R G L P M F E L V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_650452 668 74736 R574 Q L Y L H P M R C A S G A T V
Honey Bee Apis mellifera XP_393739 477 54008 D422 P S Y L V P E D E K I D Y P M
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786847 723 81931 G664 P T V V S P L G S H S S D Y P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8S929 467 51510 C409 S L A L G F Y C R D K D D F D
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q7S3X7 506 55337 S458 D D W D T W K S S V K H V Q G
Conservation
Percent
Protein Identity: 100 79.9 98.2 94.5 N.A. 90.3 89.5 N.A. 83.2 28.1 68.1 26.8 N.A. 26.5 30.3 N.A. 28
Protein Similarity: 100 79.9 98.9 97.3 N.A. 95.6 95.4 N.A. 88 42.5 82.7 46 N.A. 42 46.3 N.A. 41.4
P-Site Identity: 100 6.6 100 93.3 N.A. 93.3 93.3 N.A. 86.6 13.3 66.6 13.3 N.A. 6.6 6.6 N.A. 0
P-Site Similarity: 100 13.3 100 93.3 N.A. 93.3 93.3 N.A. 93.3 26.6 86.6 26.6 N.A. 6.6 20 N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. 22.7 N.A. 21.5
Protein Similarity: N.A. N.A. N.A. 41.1 N.A. 39.3
P-Site Identity: N.A. N.A. N.A. 20 N.A. 13.3
P-Site Similarity: N.A. N.A. N.A. 40 N.A. 26.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 7 0 0 7 0 7 0 7 0 0 7 0 0 % A
% Cys: 0 0 0 0 0 7 0 7 14 0 0 0 0 0 0 % C
% Asp: 7 7 0 7 0 0 0 7 0 7 0 14 14 0 7 % D
% Glu: 0 0 0 0 0 0 14 0 7 40 0 0 14 0 0 % E
% Phe: 0 0 0 0 0 20 0 0 0 0 0 14 0 7 47 % F
% Gly: 0 7 0 0 7 0 7 14 0 0 7 7 0 7 14 % G
% His: 0 0 0 0 7 0 0 0 0 7 0 7 0 0 0 % H
% Ile: 0 0 7 0 0 20 0 0 0 0 7 7 7 0 0 % I
% Lys: 14 54 0 0 47 0 7 0 47 7 54 0 0 0 0 % K
% Leu: 0 20 0 80 0 7 7 0 14 0 0 0 0 60 0 % L
% Met: 0 0 34 0 0 0 7 0 0 0 14 0 0 0 7 % M
% Asn: 0 0 0 0 7 0 0 0 0 0 7 0 0 0 0 % N
% Pro: 14 0 0 0 0 20 0 0 0 14 0 0 47 7 7 % P
% Gln: 7 0 0 0 0 0 0 0 0 7 0 0 0 7 0 % Q
% Arg: 7 0 0 0 0 7 7 7 7 0 0 0 0 0 0 % R
% Ser: 7 7 7 7 14 7 47 47 14 0 14 7 0 0 0 % S
% Thr: 47 7 0 0 7 0 0 7 0 0 0 0 0 7 0 % T
% Val: 0 0 27 7 14 0 0 0 0 14 0 0 7 0 20 % V
% Trp: 0 0 7 0 0 7 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 14 0 0 0 7 7 0 0 0 47 7 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _