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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ATG4C All Species: 31.82
Human Site: S374 Identified Species: 50
UniProt: Q96DT6 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96DT6 NP_116241.2 458 52497 S374 C P S P K K M S F R K M D P S
Chimpanzee Pan troglodytes XP_001159697 366 41520 N283 S A S M T S D N A D D K A V I
Rhesus Macaque Macaca mulatta XP_001086218 458 52551 S374 C P S P K K M S F R K M D P S
Dog Lupus familis XP_852273 458 52523 S374 C P S P K K M S F R K M D P S
Cat Felis silvestris
Mouse Mus musculus Q811C2 458 52068 S374 C P S P K K M S F R K M D P S
Rat Rattus norvegicus NP_001101418 458 52091 S374 C P S P K K M S F R K M D P S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514370 459 52127 S374 C P S P K K M S F R K M D P S
Chicken Gallus gallus Q6PZ02 393 44512 I310 H P P C R M S I A E L D P S I
Frog Xenopus laevis Q5XH30 450 51749 S365 C P S P K K M S F K K M D P S
Zebra Danio Brachydanio rerio Q6DG88 394 44435 H311 Q H P P C R M H I C E L D P S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_650452 668 74736 K539 C K S P R K L K A S K M D P S
Honey Bee Apis mellifera XP_393739 477 54008 L387 C T S P R K M L I S K M D P S
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786847 723 81931 S629 C M S P R K M S I S K M D P S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8S929 467 51510 V374 E V Q Q V V T V N K E T P D V
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q7S3X7 506 55337 T423 Y T A E E L D T C H T R R L R
Conservation
Percent
Protein Identity: 100 79.9 98.2 94.5 N.A. 90.3 89.5 N.A. 83.2 28.1 68.1 26.8 N.A. 26.5 30.3 N.A. 28
Protein Similarity: 100 79.9 98.9 97.3 N.A. 95.6 95.4 N.A. 88 42.5 82.7 46 N.A. 42 46.3 N.A. 41.4
P-Site Identity: 100 6.6 100 100 N.A. 100 100 N.A. 100 6.6 93.3 33.3 N.A. 60 66.6 N.A. 73.3
P-Site Similarity: 100 13.3 100 100 N.A. 100 100 N.A. 100 13.3 100 53.3 N.A. 73.3 73.3 N.A. 80
Percent
Protein Identity: N.A. N.A. N.A. 22.7 N.A. 21.5
Protein Similarity: N.A. N.A. N.A. 41.1 N.A. 39.3
P-Site Identity: N.A. N.A. N.A. 0 N.A. 0
P-Site Similarity: N.A. N.A. N.A. 13.3 N.A. 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 7 0 0 0 0 0 20 0 0 0 7 0 0 % A
% Cys: 67 0 0 7 7 0 0 0 7 7 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 14 0 0 7 7 7 74 7 0 % D
% Glu: 7 0 0 7 7 0 0 0 0 7 14 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 47 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 7 7 0 0 0 0 0 7 0 7 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 7 20 0 0 0 0 0 14 % I
% Lys: 0 7 0 0 47 67 0 7 0 14 67 7 0 0 0 % K
% Leu: 0 0 0 0 0 7 7 7 0 0 7 7 0 7 0 % L
% Met: 0 7 0 7 0 7 67 0 0 0 0 67 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 7 7 0 0 0 0 0 0 % N
% Pro: 0 54 14 74 0 0 0 0 0 0 0 0 14 74 0 % P
% Gln: 7 0 7 7 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 27 7 0 0 0 40 0 7 7 0 7 % R
% Ser: 7 0 74 0 0 7 7 54 0 20 0 0 0 7 74 % S
% Thr: 0 14 0 0 7 0 7 7 0 0 7 7 0 0 0 % T
% Val: 0 7 0 0 7 7 0 7 0 0 0 0 0 7 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _