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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ATG4C All Species: 16.36
Human Site: S177 Identified Species: 25.71
UniProt: Q96DT6 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96DT6 NP_116241.2 458 52497 S177 E F K T P T I S L K E T I G K
Chimpanzee Pan troglodytes XP_001159697 366 41520 A102 F P Q I E G S A L T T D C G W
Rhesus Macaque Macaca mulatta XP_001086218 458 52551 S177 E L K T S K I S L K E T I G K
Dog Lupus familis XP_852273 458 52523 S177 E L K T P T V S Q K E T I R R
Cat Felis silvestris
Mouse Mus musculus Q811C2 458 52068 S177 E L R T P A V S L K E T S G K
Rat Rattus norvegicus NP_001101418 458 52091 S177 E L R T P A V S L K E T S G K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514370 459 52127 S177 D P R P P S A S R N A P R G S
Chicken Gallus gallus Q6PZ02 393 44512 Q129 Y S I H Q I A Q M G V G E G K
Frog Xenopus laevis Q5XH30 450 51749 Q178 E Y V S L G K Q P L Q N S E K
Zebra Danio Brachydanio rerio Q6DG88 394 44435 Q130 Y S I H Q I A Q M G V G E G K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_650452 668 74736 V240 P Q Q I D E I V V P Q E L G M
Honey Bee Apis mellifera XP_393739 477 54008 W192 F L G R E W R W Q P D Q P I K
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786847 723 81931 L432 H S L I L H F L G R E W N I Y
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8S929 467 51510 L183 Q M L F A Q A L L F H R L G R
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q7S3X7 506 55337 N237 S G Q S L L A N A I L I A R L
Conservation
Percent
Protein Identity: 100 79.9 98.2 94.5 N.A. 90.3 89.5 N.A. 83.2 28.1 68.1 26.8 N.A. 26.5 30.3 N.A. 28
Protein Similarity: 100 79.9 98.9 97.3 N.A. 95.6 95.4 N.A. 88 42.5 82.7 46 N.A. 42 46.3 N.A. 41.4
P-Site Identity: 100 13.3 80 66.6 N.A. 66.6 66.6 N.A. 20 13.3 13.3 13.3 N.A. 13.3 6.6 N.A. 6.6
P-Site Similarity: 100 26.6 80 80 N.A. 80 80 N.A. 40 20 33.3 20 N.A. 40 13.3 N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. 22.7 N.A. 21.5
Protein Similarity: N.A. N.A. N.A. 41.1 N.A. 39.3
P-Site Identity: N.A. N.A. N.A. 13.3 N.A. 0
P-Site Similarity: N.A. N.A. N.A. 33.3 N.A. 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 7 14 34 7 7 0 7 0 7 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % C
% Asp: 7 0 0 0 7 0 0 0 0 0 7 7 0 0 0 % D
% Glu: 40 0 0 0 14 7 0 0 0 0 40 7 14 7 0 % E
% Phe: 14 7 0 7 0 0 7 0 0 7 0 0 0 0 0 % F
% Gly: 0 7 7 0 0 14 0 0 7 14 0 14 0 67 0 % G
% His: 7 0 0 14 0 7 0 0 0 0 7 0 0 0 0 % H
% Ile: 0 0 14 20 0 14 20 0 0 7 0 7 20 14 0 % I
% Lys: 0 0 20 0 0 7 7 0 0 34 0 0 0 0 54 % K
% Leu: 0 34 14 0 20 7 0 14 40 7 7 0 14 0 7 % L
% Met: 0 7 0 0 0 0 0 0 14 0 0 0 0 0 7 % M
% Asn: 0 0 0 0 0 0 0 7 0 7 0 7 7 0 0 % N
% Pro: 7 14 0 7 34 0 0 0 7 14 0 7 7 0 0 % P
% Gln: 7 7 20 0 14 7 0 20 14 0 14 7 0 0 0 % Q
% Arg: 0 0 20 7 0 0 7 0 7 7 0 7 7 14 14 % R
% Ser: 7 20 0 14 7 7 7 40 0 0 0 0 20 0 7 % S
% Thr: 0 0 0 34 0 14 0 0 0 7 7 34 0 0 0 % T
% Val: 0 0 7 0 0 0 20 7 7 0 14 0 0 0 0 % V
% Trp: 0 0 0 0 0 7 0 7 0 0 0 7 0 0 7 % W
% Tyr: 14 7 0 0 0 0 0 0 0 0 0 0 0 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _