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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ATG4C All Species: 24.85
Human Site: S144 Identified Species: 39.05
UniProt: Q96DT6 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96DT6 NP_116241.2 458 52497 S144 D A L N I E N S D S E S W T S
Chimpanzee Pan troglodytes XP_001159697 366 41520 D69 E S G C T I E D H V I A G N V
Rhesus Macaque Macaca mulatta XP_001086218 458 52551 S144 D A L N I E N S D S E S W T S
Dog Lupus familis XP_852273 458 52523 S144 D A L N I E N S D S D S W T S
Cat Felis silvestris
Mouse Mus musculus Q811C2 458 52068 A144 D A L H I E N A D S D S W T S
Rat Rattus norvegicus NP_001101418 458 52091 S144 D A L H I E S S D S D S W T S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514370 459 52127 S144 A A L D M E N S D S E S W T S
Chicken Gallus gallus Q6PZ02 393 44512 R96 R H L G R D W R W I K G K R Q
Frog Xenopus laevis Q5XH30 450 51749 S145 E A L D I F C S E S D F W T A
Zebra Danio Brachydanio rerio Q6DG88 394 44435 K97 R H L G R D W K W S P G Q R Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_650452 668 74736 T207 L P S G A D T T P D N A T S A
Honey Bee Apis mellifera XP_393739 477 54008 T159 F P I L N G S T F T T D C G W
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786847 723 81931 P399 M T Y R R E F P T L A G S N F
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8S929 467 51510 Y150 S S K I L M T Y R K G F E P F
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q7S3X7 506 55337 F204 Q A S S A L S F A M R I K T T
Conservation
Percent
Protein Identity: 100 79.9 98.2 94.5 N.A. 90.3 89.5 N.A. 83.2 28.1 68.1 26.8 N.A. 26.5 30.3 N.A. 28
Protein Similarity: 100 79.9 98.9 97.3 N.A. 95.6 95.4 N.A. 88 42.5 82.7 46 N.A. 42 46.3 N.A. 41.4
P-Site Identity: 100 0 100 93.3 N.A. 80 80 N.A. 80 6.6 46.6 13.3 N.A. 0 0 N.A. 6.6
P-Site Similarity: 100 20 100 100 N.A. 100 100 N.A. 93.3 20 80 20 N.A. 33.3 26.6 N.A. 6.6
Percent
Protein Identity: N.A. N.A. N.A. 22.7 N.A. 21.5
Protein Similarity: N.A. N.A. N.A. 41.1 N.A. 39.3
P-Site Identity: N.A. N.A. N.A. 0 N.A. 13.3
P-Site Similarity: N.A. N.A. N.A. 13.3 N.A. 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 54 0 0 14 0 0 7 7 0 7 14 0 0 14 % A
% Cys: 0 0 0 7 0 0 7 0 0 0 0 0 7 0 0 % C
% Asp: 34 0 0 14 0 20 0 7 40 7 27 7 0 0 0 % D
% Glu: 14 0 0 0 0 47 7 0 7 0 20 0 7 0 0 % E
% Phe: 7 0 0 0 0 7 7 7 7 0 0 14 0 0 14 % F
% Gly: 0 0 7 20 0 7 0 0 0 0 7 20 7 7 0 % G
% His: 0 14 0 14 0 0 0 0 7 0 0 0 0 0 0 % H
% Ile: 0 0 7 7 40 7 0 0 0 7 7 7 0 0 0 % I
% Lys: 0 0 7 0 0 0 0 7 0 7 7 0 14 0 0 % K
% Leu: 7 0 60 7 7 7 0 0 0 7 0 0 0 0 0 % L
% Met: 7 0 0 0 7 7 0 0 0 7 0 0 0 0 0 % M
% Asn: 0 0 0 20 7 0 34 0 0 0 7 0 0 14 0 % N
% Pro: 0 14 0 0 0 0 0 7 7 0 7 0 0 7 0 % P
% Gln: 7 0 0 0 0 0 0 0 0 0 0 0 7 0 14 % Q
% Arg: 14 0 0 7 20 0 0 7 7 0 7 0 0 14 0 % R
% Ser: 7 14 14 7 0 0 20 40 0 54 0 40 7 7 40 % S
% Thr: 0 7 0 0 7 0 14 14 7 7 7 0 7 54 7 % T
% Val: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 7 % V
% Trp: 0 0 0 0 0 0 14 0 14 0 0 0 47 0 7 % W
% Tyr: 0 0 7 0 0 0 0 7 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _