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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AP2M1
All Species:
47.27
Human Site:
Y277
Identified Species:
80
UniProt:
Q96CW1
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96CW1
NP_001020376.1
435
49655
Y277
G
E
F
E
L
M
R
Y
R
T
T
K
D
I
I
Chimpanzee
Pan troglodytes
XP_001143960
424
48467
K270
L
M
R
Y
R
T
T
K
D
I
I
L
P
F
R
Rhesus Macaque
Macaca mulatta
XP_001102323
427
48656
Y269
G
E
F
E
L
M
R
Y
R
T
T
K
D
I
I
Dog
Lupus familis
XP_858405
437
49906
Y279
G
E
F
E
L
M
R
Y
R
T
T
K
D
I
I
Cat
Felis silvestris
Mouse
Mus musculus
P35585
423
48524
L269
F
E
L
M
S
Y
R
L
N
T
H
V
K
P
L
Rat
Rattus norvegicus
P84092
435
49636
Y277
G
E
F
E
L
M
R
Y
R
T
T
K
D
I
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZMP6
433
49371
Y275
G
E
F
E
L
M
R
Y
R
T
T
K
D
I
I
Frog
Xenopus laevis
Q801Q8
435
49666
Y277
G
E
Y
E
L
M
R
Y
R
T
T
K
D
I
I
Zebra Danio
Brachydanio rerio
Q7ZW98
436
49724
Y278
G
E
Y
E
L
M
R
Y
R
T
T
K
D
I
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_732744
437
49837
Y279
G
E
F
E
L
M
R
Y
R
T
T
K
D
I
S
Honey Bee
Apis mellifera
XP_391965
442
49946
Y284
G
E
F
E
L
M
R
Y
R
T
T
K
D
I
S
Nematode Worm
Caenorhab. elegans
P35603
441
50282
Y281
G
E
Y
E
L
M
R
Y
R
T
T
K
D
I
Q
Sea Urchin
Strong. purpuratus
XP_801936
438
49913
Y280
G
E
F
E
L
M
K
Y
R
T
T
K
D
I
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q00776
475
53855
Y306
G
K
F
D
L
M
N
Y
R
L
S
T
T
I
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.4
96.5
99.5
N.A.
40
100
N.A.
N.A.
99
99
97.9
N.A.
87.4
85.2
81.1
86.5
Protein Similarity:
100
97.4
96.7
99.5
N.A.
61.3
100
N.A.
N.A.
99
99.5
98.6
N.A.
94.5
92.7
91.1
94.5
P-Site Identity:
100
0
100
100
N.A.
20
100
N.A.
N.A.
100
93.3
93.3
N.A.
93.3
93.3
86.6
86.6
P-Site Similarity:
100
0
100
100
N.A.
26.6
100
N.A.
N.A.
100
100
100
N.A.
93.3
93.3
93.3
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
36.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
57.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
46.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
0
0
0
0
8
0
0
0
79
0
0
% D
% Glu:
0
86
0
79
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
8
0
65
0
0
0
0
0
0
0
0
0
0
8
0
% F
% Gly:
86
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
8
8
0
0
86
50
% I
% Lys:
0
8
0
0
0
0
8
8
0
0
0
79
8
0
8
% K
% Leu:
8
0
8
0
86
0
0
8
0
8
0
8
0
0
8
% L
% Met:
0
8
0
8
0
86
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
8
0
8
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
8
8
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% Q
% Arg:
0
0
8
0
8
0
79
0
86
0
0
0
0
0
8
% R
% Ser:
0
0
0
0
8
0
0
0
0
0
8
0
0
0
22
% S
% Thr:
0
0
0
0
0
8
8
0
0
86
79
8
8
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
22
8
0
8
0
86
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _