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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PINX1 All Species: 11.52
Human Site: S226 Identified Species: 21.11
UniProt: Q96BK5 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96BK5 NP_060354.4 328 37035 S226 A T G K D V E S Y L Q P K A K
Chimpanzee Pan troglodytes XP_519603 333 37605 S226 S T G K D V E S Y L Q P K A K
Rhesus Macaque Macaca mulatta XP_001089816 328 36769 S226 A T G E D V E S Y P Q P K A K
Dog Lupus familis XP_849859 314 35718 K222 K K R K K E A K D R K V E T Y
Cat Felis silvestris
Mouse Mus musculus Q9CZX5 332 37202 N232 A A D T D V E N S P Q H K A K
Rat Rattus norvegicus A4L691 331 36692 N232 A A G T D I E N S P Q H K A K
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_420036 356 40488 E253 A E N T E Q C E K P Q G K K C
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001013283 355 40546 T254 A A E E D M Q T R V T G E S V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_611495 726 82612 K276 R A D E P P T K E E E P E Q V
Honey Bee Apis mellifera XP_391986 378 43625 K235 S H E S D E S K E I Q T D S L
Nematode Worm Caenorhab. elegans NP_495955 339 39018 M227 A N Q T E V K M E I K T E V E
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P53335 271 31293 K182 K K H K K H K K H K K D K K K
Red Bread Mold Neurospora crassa Q7SHT5 369 41722 E228 K E K K D K K E K K D Q K E K
Conservation
Percent
Protein Identity: 100 96.6 94.2 75.9 N.A. 72.8 69.4 N.A. N.A. 48.5 N.A. 48.7 N.A. 22.7 32 28.9 N.A.
Protein Similarity: 100 97.5 96 82.6 N.A. 81 79.1 N.A. N.A. 64 N.A. 64.2 N.A. 31.5 48.4 47.4 N.A.
P-Site Identity: 100 93.3 86.6 6.6 N.A. 53.3 53.3 N.A. N.A. 20 N.A. 13.3 N.A. 6.6 13.3 13.3 N.A.
P-Site Similarity: 100 100 93.3 20 N.A. 60 66.6 N.A. N.A. 26.6 N.A. 60 N.A. 26.6 33.3 53.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 25.6 23.5
Protein Similarity: N.A. N.A. N.A. N.A. 44.2 40.6
P-Site Identity: N.A. N.A. N.A. N.A. 20 26.6
P-Site Similarity: N.A. N.A. N.A. N.A. 40 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 54 31 0 0 0 0 8 0 0 0 0 0 0 39 0 % A
% Cys: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 8 % C
% Asp: 0 0 16 0 62 0 0 0 8 0 8 8 8 0 0 % D
% Glu: 0 16 16 24 16 16 39 16 24 8 8 0 31 8 8 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 31 0 0 0 0 0 0 0 0 16 0 0 0 % G
% His: 0 8 8 0 0 8 0 0 8 0 0 16 0 0 0 % H
% Ile: 0 0 0 0 0 8 0 0 0 16 0 0 0 0 0 % I
% Lys: 24 16 8 39 16 8 24 31 16 16 24 0 62 16 54 % K
% Leu: 0 0 0 0 0 0 0 0 0 16 0 0 0 0 8 % L
% Met: 0 0 0 0 0 8 0 8 0 0 0 0 0 0 0 % M
% Asn: 0 8 8 0 0 0 0 16 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 8 8 0 0 0 31 0 31 0 0 0 % P
% Gln: 0 0 8 0 0 8 8 0 0 0 54 8 0 8 0 % Q
% Arg: 8 0 8 0 0 0 0 0 8 8 0 0 0 0 0 % R
% Ser: 16 0 0 8 0 0 8 24 16 0 0 0 0 16 0 % S
% Thr: 0 24 0 31 0 0 8 8 0 0 8 16 0 8 0 % T
% Val: 0 0 0 0 0 39 0 0 0 8 0 8 0 8 16 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 24 0 0 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _