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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ADC All Species: 23.64
Human Site: S31 Identified Species: 40
UniProt: Q96A70 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96A70 NP_443724.1 460 49980 S31 K E L T L G A S Q A T T D E V
Chimpanzee Pan troglodytes XP_524555 420 45293 S31 K E L T L G A S Q A T T D E V
Rhesus Macaque Macaca mulatta XP_001106869 460 49820 S31 K E L T L G A S E A T T D E V
Dog Lupus familis XP_535320 460 49774 S31 E E L T L G A S Q A T A G D V
Cat Felis silvestris
Mouse Mus musculus Q8BVM4 459 49484 S31 E E L T L G A S Q A T S G K V
Rat Rattus norvegicus P09057 461 51029 S32 D Q K I N E V S S S D D K D A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516497 344 37229
Chicken Gallus gallus P27118 450 49716 D34 K D A F Y V A D L G D I V K K
Frog Xenopus laevis Q9I8S4 456 50618 S31 E E I I N E V S Q T E D R D A
Zebra Danio Brachydanio rerio NP_571876 461 50770 S32 E Q K I N E S S L S D D K D A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P40807 394 44176 Q31 C D L Q R L D Q A L N I C D L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P41931 422 46901 S32 M C R D I A A S K D L Q E N D
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P08432 466 52267 E36 K Q Y Y K D G E T L H N L L L
Red Bread Mold Neurospora crassa P27121 484 53282 L65 K Q M I G D A L R Q R V E S I
Conservation
Percent
Protein Identity: 100 78.4 97.3 88.2 N.A. 86 49 N.A. 50.6 49.3 60 50.5 N.A. 35 N.A. 31.5 N.A.
Protein Similarity: 100 81.7 98.4 93 N.A. 92.6 70.9 N.A. 61.2 68.9 77.1 70.5 N.A. 52.8 N.A. 54.1 N.A.
P-Site Identity: 100 100 93.3 73.3 N.A. 73.3 6.6 N.A. 0 13.3 20 6.6 N.A. 6.6 N.A. 13.3 N.A.
P-Site Similarity: 100 100 100 86.6 N.A. 93.3 26.6 N.A. 0 26.6 40 40 N.A. 26.6 N.A. 33.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 34.9 32.8
Protein Similarity: N.A. N.A. N.A. N.A. 53.6 50.6
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 13.3
P-Site Similarity: N.A. N.A. N.A. N.A. 20 46.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 0 0 8 58 0 8 36 0 8 0 0 22 % A
% Cys: 8 8 0 0 0 0 0 0 0 0 0 0 8 0 0 % C
% Asp: 8 15 0 8 0 15 8 8 0 8 22 22 22 36 8 % D
% Glu: 29 43 0 0 0 22 0 8 8 0 8 0 15 22 0 % E
% Phe: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 8 36 8 0 0 8 0 0 15 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % H
% Ile: 0 0 8 29 8 0 0 0 0 0 0 15 0 0 8 % I
% Lys: 43 0 15 0 8 0 0 0 8 0 0 0 15 15 8 % K
% Leu: 0 0 43 0 36 8 0 8 15 15 8 0 8 8 15 % L
% Met: 8 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 22 0 0 0 0 0 8 8 0 8 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 29 0 8 0 0 0 8 36 8 0 8 0 0 0 % Q
% Arg: 0 0 8 0 8 0 0 0 8 0 8 0 8 0 0 % R
% Ser: 0 0 0 0 0 0 8 65 8 15 0 8 0 8 0 % S
% Thr: 0 0 0 36 0 0 0 0 8 8 36 22 0 0 0 % T
% Val: 0 0 0 0 0 8 15 0 0 0 0 8 8 0 36 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 8 8 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _