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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ISL2
All Species:
19.39
Human Site:
S99
Identified Species:
38.79
UniProt:
Q96A47
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96A47
NP_665804.1
359
39768
S99
C
Q
V
G
F
S
S
S
D
L
V
M
R
A
R
Chimpanzee
Pan troglodytes
Q5IS44
406
44776
S137
L
H
S
A
T
T
G
S
D
P
S
L
S
P
D
Rhesus Macaque
Macaca mulatta
XP_001105068
359
39766
S99
C
Q
V
G
F
S
S
S
D
L
V
M
R
A
R
Dog
Lupus familis
XP_867861
345
38655
Y97
M
R
A
R
S
K
V
Y
H
I
E
C
F
R
C
Cat
Felis silvestris
Mouse
Mus musculus
Q9CXV0
359
39637
S99
C
Q
V
G
F
S
S
S
D
L
V
M
R
A
R
Rat
Rattus norvegicus
P50480
360
39657
S99
C
Q
V
G
F
S
S
S
D
L
V
M
R
A
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508080
665
71117
N405
C
S
I
G
F
S
K
N
D
F
V
M
R
A
R
Chicken
Gallus gallus
P50211
349
39015
A97
D
F
V
M
R
A
R
A
K
V
Y
H
I
E
C
Frog
Xenopus laevis
P29674
403
44916
P138
I
S
V
T
G
S
D
P
S
L
S
P
E
S
Q
Zebra Danio
Brachydanio rerio
P53406
359
40208
S99
C
N
I
G
F
C
S
S
D
L
V
M
R
A
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_476775
534
58026
N126
C
G
N
S
F
S
K
N
D
F
V
M
R
A
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781774
401
45310
N123
C
S
Q
G
F
T
K
N
D
F
V
M
R
A
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
30.5
99.7
73.8
N.A.
97.4
96.3
N.A.
40.9
74
29.5
88
N.A.
42.7
N.A.
N.A.
56.8
Protein Similarity:
100
45.5
100
83.5
N.A.
98.3
97.2
N.A.
47
83.8
46.9
92.7
N.A.
50.3
N.A.
N.A.
67.8
P-Site Identity:
100
13.3
100
0
N.A.
100
100
N.A.
66.6
6.6
20
80
N.A.
53.3
N.A.
N.A.
60
P-Site Similarity:
100
26.6
100
13.3
N.A.
100
100
N.A.
80
26.6
33.3
86.6
N.A.
66.6
N.A.
N.A.
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
9
9
0
9
0
9
0
0
0
0
0
67
0
% A
% Cys:
67
0
0
0
0
9
0
0
0
0
0
9
0
0
17
% C
% Asp:
9
0
0
0
0
0
9
0
75
0
0
0
0
0
9
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
9
0
9
9
0
% E
% Phe:
0
9
0
0
67
0
0
0
0
25
0
0
9
0
0
% F
% Gly:
0
9
0
59
9
0
9
0
0
0
0
0
0
0
0
% G
% His:
0
9
0
0
0
0
0
0
9
0
0
9
0
0
0
% H
% Ile:
9
0
17
0
0
0
0
0
0
9
0
0
9
0
0
% I
% Lys:
0
0
0
0
0
9
25
0
9
0
0
0
0
0
9
% K
% Leu:
9
0
0
0
0
0
0
0
0
50
0
9
0
0
0
% L
% Met:
9
0
0
9
0
0
0
0
0
0
0
67
0
0
0
% M
% Asn:
0
9
9
0
0
0
0
25
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
9
0
9
0
9
0
9
0
% P
% Gln:
0
34
9
0
0
0
0
0
0
0
0
0
0
0
9
% Q
% Arg:
0
9
0
9
9
0
9
0
0
0
0
0
67
9
59
% R
% Ser:
0
25
9
9
9
59
42
50
9
0
17
0
9
9
0
% S
% Thr:
0
0
0
9
9
17
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
50
0
0
0
9
0
0
9
67
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
9
0
0
9
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _