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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ISL2
All Species:
20
Human Site:
S174
Identified Species:
40
UniProt:
Q96A47
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96A47
NP_665804.1
359
39768
S174
L
H
L
P
D
A
G
S
G
R
Q
P
A
L
R
Chimpanzee
Pan troglodytes
Q5IS44
406
44776
N220
L
A
Q
E
T
G
L
N
M
R
V
I
Q
V
W
Rhesus Macaque
Macaca mulatta
XP_001105068
359
39766
S174
L
H
L
P
D
A
G
S
G
R
Q
P
A
L
R
Dog
Lupus familis
XP_867861
345
38655
Q163
P
D
P
I
S
A
R
Q
P
A
L
R
P
H
V
Cat
Felis silvestris
Mouse
Mus musculus
Q9CXV0
359
39637
S174
L
H
L
P
D
A
G
S
G
R
Q
P
S
L
R
Rat
Rattus norvegicus
P50480
360
39657
S175
L
H
L
P
D
A
G
S
G
Q
Q
V
S
L
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508080
665
71117
S480
Q
M
A
A
E
P
I
S
A
R
Q
P
A
L
R
Chicken
Gallus gallus
P50211
349
39015
S164
Q
M
A
A
E
P
I
S
A
R
Q
P
A
L
R
Frog
Xenopus laevis
P29674
403
44916
N219
L
A
Q
E
T
G
L
N
M
R
V
I
Q
V
W
Zebra Danio
Brachydanio rerio
P53406
359
40208
P174
L
H
I
P
E
P
V
P
V
R
Q
P
P
H
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_476775
534
58026
S224
D
S
G
S
E
S
G
S
H
K
S
I
R
D
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781774
401
45310
M195
I
S
T
R
A
E
P
M
P
N
R
T
S
S
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
30.5
99.7
73.8
N.A.
97.4
96.3
N.A.
40.9
74
29.5
88
N.A.
42.7
N.A.
N.A.
56.8
Protein Similarity:
100
45.5
100
83.5
N.A.
98.3
97.2
N.A.
47
83.8
46.9
92.7
N.A.
50.3
N.A.
N.A.
67.8
P-Site Identity:
100
13.3
100
6.6
N.A.
93.3
80
N.A.
46.6
46.6
13.3
46.6
N.A.
13.3
N.A.
N.A.
0
P-Site Similarity:
100
26.6
100
6.6
N.A.
100
93.3
N.A.
53.3
53.3
26.6
60
N.A.
40
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
17
17
17
9
42
0
0
17
9
0
0
34
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
9
0
0
34
0
0
0
0
0
0
0
0
9
0
% D
% Glu:
0
0
0
17
34
9
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
9
0
0
17
42
0
34
0
0
0
0
0
9
% G
% His:
0
42
0
0
0
0
0
0
9
0
0
0
0
17
0
% H
% Ile:
9
0
9
9
0
0
17
0
0
0
0
25
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
9
% K
% Leu:
59
0
34
0
0
0
17
0
0
0
9
0
0
50
0
% L
% Met:
0
17
0
0
0
0
0
9
17
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
17
0
9
0
0
0
0
0
% N
% Pro:
9
0
9
42
0
25
9
9
17
0
0
50
17
0
0
% P
% Gln:
17
0
17
0
0
0
0
9
0
9
59
0
17
0
0
% Q
% Arg:
0
0
0
9
0
0
9
0
0
67
9
9
9
0
59
% R
% Ser:
0
17
0
9
9
9
0
59
0
0
9
0
25
9
0
% S
% Thr:
0
0
9
0
17
0
0
0
0
0
0
9
0
0
0
% T
% Val:
0
0
0
0
0
0
9
0
9
0
17
9
0
17
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
17
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _