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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC10
All Species:
15.76
Human Site:
S450
Identified Species:
28.89
UniProt:
Q969S8
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q969S8
NP_001152758.1
669
71445
S450
A
W
A
R
P
H
E
S
L
A
R
E
E
A
L
Chimpanzee
Pan troglodytes
XP_515218
669
71461
S450
A
W
A
R
P
H
E
S
L
A
R
E
E
A
L
Rhesus Macaque
Macaca mulatta
XP_001112365
671
71733
S452
A
W
A
R
P
H
E
S
L
A
R
E
E
A
L
Dog
Lupus familis
XP_848669
830
88564
A451
A
W
A
R
L
H
E
A
L
A
Q
D
T
A
F
Cat
Felis silvestris
Mouse
Mus musculus
Q6P3E7
666
72091
S448
A
W
A
R
L
H
K
S
R
F
Q
D
E
D
L
Rat
Rattus norvegicus
Q569C4
588
63939
S389
A
W
A
R
L
H
K
S
Q
F
Q
D
D
D
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509232
334
36373
K172
L
K
S
F
I
P
P
K
G
G
K
F
F
L
M
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001089352
683
76715
L450
S
S
S
L
P
N
E
L
L
E
K
E
T
M
L
Zebra Danio
Brachydanio rerio
NP_956069
676
74999
H454
R
I
R
D
K
H
F
H
D
L
T
D
Q
N
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_727843
1138
125987
Q566
N
D
T
G
H
P
E
Q
P
S
R
I
Q
H
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q20296
955
106730
R521
F
N
S
I
Y
L
T
R
D
T
L
K
V
A
R
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8LRK8
682
76616
D507
E
S
L
Q
Q
E
R
D
E
A
V
A
K
A
E
Baker's Yeast
Sacchar. cerevisiae
P53973
706
80051
L525
V
I
S
G
T
I
D
L
S
S
S
V
I
I
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
95.2
63.8
N.A.
75.4
66.3
N.A.
33
N.A.
48.6
45.1
N.A.
26.1
N.A.
23
N.A.
Protein Similarity:
100
99.4
97.1
69.8
N.A.
83.2
72.8
N.A.
40.2
N.A.
65
61.3
N.A.
36.7
N.A.
39.2
N.A.
P-Site Identity:
100
100
100
60
N.A.
53.3
46.6
N.A.
0
N.A.
33.3
6.6
N.A.
13.3
N.A.
6.6
N.A.
P-Site Similarity:
100
100
100
80
N.A.
73.3
73.3
N.A.
20
N.A.
60
26.6
N.A.
33.3
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
29.1
24.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
45.7
45.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
47
0
47
0
0
0
0
8
0
39
0
8
0
47
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
0
8
0
0
8
8
16
0
0
31
8
16
8
% D
% Glu:
8
0
0
0
0
8
47
0
8
8
0
31
31
0
8
% E
% Phe:
8
0
0
8
0
0
8
0
0
16
0
8
8
0
8
% F
% Gly:
0
0
0
16
0
0
0
0
8
8
0
0
0
0
0
% G
% His:
0
0
0
0
8
54
0
8
0
0
0
0
0
8
0
% H
% Ile:
0
16
0
8
8
8
0
0
0
0
0
8
8
8
16
% I
% Lys:
0
8
0
0
8
0
16
8
0
0
16
8
8
0
0
% K
% Leu:
8
0
8
8
24
8
0
16
39
8
8
0
0
8
47
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
8
% M
% Asn:
8
8
0
0
0
8
0
0
0
0
0
0
0
8
0
% N
% Pro:
0
0
0
0
31
16
8
0
8
0
0
0
0
0
0
% P
% Gln:
0
0
0
8
8
0
0
8
8
0
24
0
16
0
0
% Q
% Arg:
8
0
8
47
0
0
8
8
8
0
31
0
0
0
8
% R
% Ser:
8
16
31
0
0
0
0
39
8
16
8
0
0
0
0
% S
% Thr:
0
0
8
0
8
0
8
0
0
8
8
0
16
0
0
% T
% Val:
8
0
0
0
0
0
0
0
0
0
8
8
8
0
0
% V
% Trp:
0
47
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _