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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC10
All Species:
9.7
Human Site:
S373
Identified Species:
17.78
UniProt:
Q969S8
Number Species:
12
Phosphosite Substitution
Charge Score:
0.5
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q969S8
NP_001152758.1
669
71445
S373
P
M
S
P
S
S
H
S
P
E
G
R
P
P
P
Chimpanzee
Pan troglodytes
XP_515218
669
71461
S373
P
M
S
P
S
S
H
S
P
E
G
R
P
P
P
Rhesus Macaque
Macaca mulatta
XP_001112365
671
71733
S373
P
T
S
P
S
T
H
S
P
E
G
R
P
P
P
Dog
Lupus familis
XP_848669
830
88564
G373
P
G
T
C
S
A
D
G
R
T
S
L
V
L
P
Cat
Felis silvestris
Mouse
Mus musculus
Q6P3E7
666
72091
E373
S
S
S
T
H
S
P
E
E
R
S
L
R
L
L
Rat
Rattus norvegicus
Q569C4
588
63939
S317
C
S
D
S
P
D
P
S
L
D
K
P
P
T
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509232
334
36373
E100
D
A
V
Y
F
H
P
E
S
Y
R
C
A
R
L
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001089352
683
76715
D375
H
D
P
S
S
E
G
D
S
Q
H
S
S
D
Q
Zebra Danio
Brachydanio rerio
NP_956069
676
74999
D375
N
P
K
R
P
R
L
D
A
T
N
G
G
P
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_727843
1138
125987
D485
C
V
E
L
Q
D
R
D
K
E
E
D
L
H
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q20296
955
106730
I383
L
R
L
A
Q
W
P
I
V
N
T
K
V
I
Y
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8LRK8
682
76616
E432
N
L
K
N
P
S
A
E
R
N
S
A
D
A
L
Baker's Yeast
Sacchar. cerevisiae
P53973
706
80051
I446
G
C
N
F
N
E
P
I
N
D
S
I
I
S
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
95.2
63.8
N.A.
75.4
66.3
N.A.
33
N.A.
48.6
45.1
N.A.
26.1
N.A.
23
N.A.
Protein Similarity:
100
99.4
97.1
69.8
N.A.
83.2
72.8
N.A.
40.2
N.A.
65
61.3
N.A.
36.7
N.A.
39.2
N.A.
P-Site Identity:
100
100
86.6
20
N.A.
13.3
13.3
N.A.
0
N.A.
6.6
6.6
N.A.
6.6
N.A.
0
N.A.
P-Site Similarity:
100
100
93.3
33.3
N.A.
13.3
20
N.A.
0
N.A.
13.3
6.6
N.A.
13.3
N.A.
6.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
29.1
24.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
45.7
45.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
8
0
8
8
0
8
0
0
8
8
8
0
% A
% Cys:
16
8
0
8
0
0
0
0
0
0
0
8
0
0
0
% C
% Asp:
8
8
8
0
0
16
8
24
0
16
0
8
8
8
0
% D
% Glu:
0
0
8
0
0
16
0
24
8
31
8
0
0
0
0
% E
% Phe:
0
0
0
8
8
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
8
0
0
0
0
8
8
0
0
24
8
8
0
0
% G
% His:
8
0
0
0
8
8
24
0
0
0
8
0
0
8
0
% H
% Ile:
0
0
0
0
0
0
0
16
0
0
0
8
8
8
0
% I
% Lys:
0
0
16
0
0
0
0
0
8
0
8
8
0
0
16
% K
% Leu:
8
8
8
8
0
0
8
0
8
0
0
16
8
16
24
% L
% Met:
0
16
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
16
0
8
8
8
0
0
0
8
16
8
0
0
0
8
% N
% Pro:
31
8
8
24
24
0
39
0
24
0
0
8
31
31
31
% P
% Gln:
0
0
0
0
16
0
0
0
0
8
0
0
0
0
8
% Q
% Arg:
0
8
0
8
0
8
8
0
16
8
8
24
8
8
0
% R
% Ser:
8
16
31
16
39
31
0
31
16
0
31
8
8
8
0
% S
% Thr:
0
8
8
8
0
8
0
0
0
16
8
0
0
8
8
% T
% Val:
0
8
8
0
0
0
0
0
8
0
0
0
16
0
0
% V
% Trp:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
0
0
0
8
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _