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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP1MT
All Species:
40.61
Human Site:
Y374
Identified Species:
63.81
UniProt:
Q969P6
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q969P6
NP_443195.1
601
69872
Y374
G
K
D
C
I
R
Y
Y
N
R
V
P
V
E
K
Chimpanzee
Pan troglodytes
A9Q1D5
601
69739
Y374
G
K
D
C
I
R
Y
Y
N
R
V
P
V
E
K
Rhesus Macaque
Macaca mulatta
XP_001088021
767
90935
Y540
G
K
D
S
I
R
Y
Y
N
K
V
P
V
E
K
Dog
Lupus familis
XP_534420
1004
115318
Y777
G
K
D
S
I
R
Y
Y
N
K
V
P
V
E
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8R4U6
593
68985
K367
G
K
D
S
I
R
Y
K
N
H
V
T
V
E
K
Rat
Rattus norvegicus
Q6IM78
593
68993
K367
G
K
D
S
I
R
Y
K
N
H
V
T
V
E
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519186
689
80888
Y462
G
K
D
S
I
R
Y
Y
N
K
V
P
V
E
K
Chicken
Gallus gallus
NP_001001300
593
69066
Y366
G
K
D
S
I
R
Y
Y
N
K
V
S
V
E
K
Frog
Xenopus laevis
P41512
829
98212
Y594
G
K
D
S
I
R
Y
Y
N
K
V
P
V
E
K
Zebra Danio
Brachydanio rerio
NP_001037789
758
89767
Y531
G
K
D
S
I
R
Y
Y
N
K
V
P
V
E
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30189
972
111670
Y760
G
K
D
S
I
R
Y
Y
N
E
V
E
V
E
K
Honey Bee
Apis mellifera
XP_396203
973
114099
Y763
G
K
D
S
I
R
Y
Y
N
E
V
P
V
E
K
Nematode Worm
Caenorhab. elegans
O17966
806
94011
F587
G
K
D
S
I
R
Y
F
N
R
V
S
V
E
K
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30181
916
102780
V684
G
K
D
S
I
Q
Y
V
N
T
V
E
V
E
P
Baker's Yeast
Sacchar. cerevisiae
P04786
769
89977
Y464
G
K
D
S
I
R
F
Y
Q
E
V
E
V
D
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.8
53.9
43.5
N.A.
73.5
75
N.A.
67.7
73.5
48.1
54.8
N.A.
38.5
40.7
45
N.A.
Protein Similarity:
100
99.5
67.2
52.3
N.A.
83.6
84.8
N.A.
78.5
86.3
60.3
67.1
N.A.
47.9
49.5
57.4
N.A.
P-Site Identity:
100
100
86.6
86.6
N.A.
73.3
73.3
N.A.
86.6
80
86.6
86.6
N.A.
80
86.6
80
N.A.
P-Site Similarity:
100
100
93.3
93.3
N.A.
73.3
73.3
N.A.
93.3
86.6
93.3
93.3
N.A.
80
86.6
86.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
32.5
40.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
45.4
55.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
60
60
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
66.6
73.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
14
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
100
0
0
0
0
0
0
0
0
0
0
7
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
20
0
20
0
94
0
% E
% Phe:
0
0
0
0
0
0
7
7
0
0
0
0
0
0
0
% F
% Gly:
100
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
14
0
0
0
0
0
% H
% Ile:
0
0
0
0
100
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
100
0
0
0
0
0
14
0
40
0
0
0
0
94
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
94
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
54
0
0
7
% P
% Gln:
0
0
0
0
0
7
0
0
7
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
94
0
0
0
20
0
0
0
0
0
% R
% Ser:
0
0
0
87
0
0
0
0
0
0
0
14
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
7
0
14
0
0
0
% T
% Val:
0
0
0
0
0
0
0
7
0
0
100
0
100
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
94
74
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _