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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP1MT
All Species:
6.36
Human Site:
T34
Identified Species:
10
UniProt:
Q969P6
Number Species:
14
Phosphosite Substitution
Charge Score:
0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q969P6
NP_443195.1
601
69872
T34
G
V
P
G
S
R
R
T
Q
K
G
S
G
A
R
Chimpanzee
Pan troglodytes
A9Q1D5
601
69739
T34
G
V
P
G
S
R
R
T
Q
K
G
S
G
A
R
Rhesus Macaque
Macaca mulatta
XP_001088021
767
90935
V96
E
K
R
K
E
E
K
V
R
A
S
G
D
A
K
Dog
Lupus familis
XP_534420
1004
115318
E289
K
S
K
H
S
N
S
E
H
K
D
S
E
K
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8R4U6
593
68985
A31
Q
V
S
R
V
A
K
A
N
R
A
G
W
E
E
Rat
Rattus norvegicus
Q6IM78
593
68993
A31
Q
V
S
R
G
S
K
A
S
R
A
G
W
G
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519186
689
80888
E109
K
G
K
S
K
N
E
E
K
S
E
R
S
D
K
Chicken
Gallus gallus
NP_001001300
593
69066
S28
P
T
A
L
R
A
G
S
G
G
C
S
R
W
E
Frog
Xenopus laevis
P41512
829
98212
K238
I
K
P
K
K
K
S
K
A
K
G
N
E
E
G
Zebra Danio
Brachydanio rerio
NP_001037789
758
89767
L72
K
D
K
E
R
Q
K
L
K
D
G
S
S
D
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30189
972
111670
S88
D
K
D
R
H
K
S
S
S
S
S
S
K
H
R
Honey Bee
Apis mellifera
XP_396203
973
114099
D111
S
N
K
D
K
D
K
D
R
K
S
S
S
S
S
Nematode Worm
Caenorhab. elegans
O17966
806
94011
K109
S
K
K
N
N
K
K
K
A
Q
E
S
S
E
D
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30181
916
102780
E150
Q
V
S
S
P
Q
P
E
K
K
N
N
G
D
R
Baker's Yeast
Sacchar. cerevisiae
P04786
769
89977
E105
K
V
K
T
T
K
K
E
E
Q
E
N
E
K
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.8
53.9
43.5
N.A.
73.5
75
N.A.
67.7
73.5
48.1
54.8
N.A.
38.5
40.7
45
N.A.
Protein Similarity:
100
99.5
67.2
52.3
N.A.
83.6
84.8
N.A.
78.5
86.3
60.3
67.1
N.A.
47.9
49.5
57.4
N.A.
P-Site Identity:
100
100
6.6
20
N.A.
6.6
6.6
N.A.
0
6.6
20
13.3
N.A.
13.3
13.3
6.6
N.A.
P-Site Similarity:
100
100
26.6
26.6
N.A.
20
20
N.A.
13.3
13.3
33.3
40
N.A.
26.6
33.3
33.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
32.5
40.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
45.4
55.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
26.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
0
0
14
0
14
14
7
14
0
0
20
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% C
% Asp:
7
7
7
7
0
7
0
7
0
7
7
0
7
20
7
% D
% Glu:
7
0
0
7
7
7
7
27
7
0
20
0
20
20
20
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
14
7
0
14
7
0
7
0
7
7
27
20
20
7
7
% G
% His:
0
0
0
7
7
0
0
0
7
0
0
0
0
7
0
% H
% Ile:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
27
27
40
14
20
27
47
14
20
40
0
0
7
14
34
% K
% Leu:
0
0
0
7
0
0
0
7
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
7
0
7
7
14
0
0
7
0
7
20
0
0
0
% N
% Pro:
7
0
20
0
7
0
7
0
0
0
0
0
0
0
0
% P
% Gln:
20
0
0
0
0
14
0
0
14
14
0
0
0
0
0
% Q
% Arg:
0
0
7
20
14
14
14
0
14
14
0
7
7
0
27
% R
% Ser:
14
7
20
14
20
7
20
14
14
14
20
54
27
7
7
% S
% Thr:
0
7
0
7
7
0
0
14
0
0
0
0
0
0
0
% T
% Val:
0
40
0
0
7
0
0
7
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
14
7
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _