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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP1MT
All Species:
19.39
Human Site:
S518
Identified Species:
30.48
UniProt:
Q969P6
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.29
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q969P6
NP_443195.1
601
69872
S518
Q
G
D
G
K
S
R
S
V
L
E
K
K
R
R
Chimpanzee
Pan troglodytes
A9Q1D5
601
69739
S518
Q
G
D
G
K
S
R
S
V
L
E
K
K
R
R
Rhesus Macaque
Macaca mulatta
XP_001088021
767
90935
K684
M
K
D
A
K
T
K
K
V
V
E
S
K
K
K
Dog
Lupus familis
XP_534420
1004
115318
K921
L
K
D
A
K
T
K
K
V
V
E
S
K
K
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8R4U6
593
68985
S511
R
G
D
S
K
P
K
S
F
L
Q
K
Q
R
R
Rat
Rattus norvegicus
Q6IM78
593
68993
S511
R
G
D
S
K
S
K
S
F
L
Q
K
Q
Q
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519186
689
80888
S606
K
K
D
I
K
S
K
S
N
L
E
K
K
K
K
Chicken
Gallus gallus
NP_001001300
593
69066
A510
K
K
D
A
K
A
E
A
N
V
Q
K
K
K
K
Frog
Xenopus laevis
P41512
829
98212
K738
R
R
D
E
K
T
K
K
L
V
E
S
K
K
K
Zebra Danio
Brachydanio rerio
NP_001037789
758
89767
K675
R
K
D
E
K
F
K
K
A
V
E
A
K
K
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30189
972
111670
D891
E
S
E
Y
H
S
R
D
E
K
K
G
K
Q
L
Honey Bee
Apis mellifera
XP_396203
973
114099
T891
N
D
A
E
L
D
S
T
Y
E
K
K
K
K
A
Nematode Worm
Caenorhab. elegans
O17966
806
94011
R718
E
A
A
L
K
S
A
R
G
A
E
K
E
K
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30181
916
102780
A835
I
R
S
L
E
P
N
A
W
E
K
K
I
A
Q
Baker's Yeast
Sacchar. cerevisiae
P04786
769
89977
T676
E
F
E
K
E
L
K
T
G
E
V
E
L
K
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.8
53.9
43.5
N.A.
73.5
75
N.A.
67.7
73.5
48.1
54.8
N.A.
38.5
40.7
45
N.A.
Protein Similarity:
100
99.5
67.2
52.3
N.A.
83.6
84.8
N.A.
78.5
86.3
60.3
67.1
N.A.
47.9
49.5
57.4
N.A.
P-Site Identity:
100
100
33.3
33.3
N.A.
53.3
53.3
N.A.
53.3
26.6
26.6
26.6
N.A.
20
13.3
26.6
N.A.
P-Site Similarity:
100
100
66.6
66.6
N.A.
80
86.6
N.A.
80
73.3
73.3
60
N.A.
46.6
33.3
46.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
32.5
40.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
45.4
55.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
14
20
0
7
7
14
7
7
0
7
0
7
14
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
67
0
0
7
0
7
0
0
0
0
0
0
0
% D
% Glu:
20
0
14
20
14
0
7
0
7
20
54
7
7
0
0
% E
% Phe:
0
7
0
0
0
7
0
0
14
0
0
0
0
0
0
% F
% Gly:
0
27
0
14
0
0
0
0
14
0
0
7
0
0
0
% G
% His:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
7
0
0
7
0
0
0
0
0
0
0
0
7
0
0
% I
% Lys:
14
34
0
7
74
0
54
27
0
7
20
60
67
60
40
% K
% Leu:
7
0
0
14
7
7
0
0
7
34
0
0
7
0
7
% L
% Met:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
7
0
0
0
0
0
7
0
14
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
14
0
0
0
0
0
0
0
0
0
% P
% Gln:
14
0
0
0
0
0
0
0
0
0
20
0
14
14
7
% Q
% Arg:
27
14
0
0
0
0
20
7
0
0
0
0
0
20
27
% R
% Ser:
0
7
7
14
0
40
7
34
0
0
0
20
0
0
7
% S
% Thr:
0
0
0
0
0
20
0
14
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
27
34
7
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% W
% Tyr:
0
0
0
7
0
0
0
0
7
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _