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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: COPS5 All Species: 53.64
Human Site: Y228 Identified Species: 69.41
UniProt: Q92905 Number Species: 17
    Phosphosite Substitution
    Charge Score: 0.06
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92905 NP_006828.2 334 37579 Y228 Y Y A L E V S Y F K S S L D R
Chimpanzee Pan troglodytes XP_522159 334 37588 Y228 Y Y A L E V S Y F K S S L D R
Rhesus Macaque Macaca mulatta XP_001097650 268 29954 F163 Y A L E V S Y F K S S L D R K
Dog Lupus familis XP_535093 334 37546 Y228 Y Y A L E V S Y F K S S L D R
Cat Felis silvestris
Mouse Mus musculus O35864 334 37530 Y228 Y Y A L E V S Y F K S S L D R
Rat Rattus norvegicus NP_001020866 334 37560 Y228 Y Y A L E V S Y F K S S L D R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512862 334 37512 Y228 Y Y A L E V S Y F K S S L D R
Chicken Gallus gallus NP_001034400 338 37847 Y232 Y Y A L E V S Y F K S S L D R
Frog Xenopus laevis Q6GLM9 332 37492 Y226 Y Y A L E V T Y F K S S L D R
Zebra Danio Brachydanio rerio Q6PC30 334 37563 Y226 Y Y A L E V S Y F K S S L D R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9XZ58 327 37065 P220 V H C K Q Y Y P L E I S Y F K
Honey Bee Apis mellifera XP_623806 344 38683 Y231 Y Y S L E V S Y F K S S L D R
Nematode Worm Caenorhab. elegans P91001 368 40990 F229 Y Y S L D V S F F K S Q L D A
Sea Urchin Strong. purpuratus XP_001190460 287 32154 Y182 Y Y S L E I S Y F K S V L D R
Poplar Tree Populus trichocarpa XP_002324396 366 40869 Y243 Y Y A L D I T Y F K S S L D C
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8LAZ7 357 39713 Y232 Y Y S L D I T Y F K S S L D S
Baker's Yeast Sacchar. cerevisiae Q12468 440 50793 E258 H C V I E D D E S E Q I S L N
Red Bread Mold Neurospora crassa Q7RXX8 336 37444 H220 Y Y A L D V E H F K S T L D S
Conservation
Percent
Protein Identity: 100 99.6 80.2 99.6 N.A. 99.4 99 N.A. 99 97.9 96.4 96.1 N.A. 73.6 78.7 50.5 74.8
Protein Similarity: 100 99.6 80.2 100 N.A. 100 99.6 N.A. 100 98.8 98.1 98.1 N.A. 86.2 87.7 65.4 80.8
P-Site Identity: 100 100 13.3 100 N.A. 100 100 N.A. 100 100 93.3 100 N.A. 6.6 93.3 66.6 80
P-Site Similarity: 100 100 26.6 100 N.A. 100 100 N.A. 100 100 100 100 N.A. 33.3 100 86.6 93.3
Percent
Protein Identity: 62.8 N.A. N.A. 63.5 27.2 49.4
Protein Similarity: 74 N.A. N.A. 75.3 46.1 65.1
P-Site Identity: 73.3 N.A. N.A. 66.6 6.6 66.6
P-Site Similarity: 93.3 N.A. N.A. 93.3 26.6 86.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 6 62 0 0 0 0 0 0 0 0 0 0 0 6 % A
% Cys: 0 6 6 0 0 0 0 0 0 0 0 0 0 0 6 % C
% Asp: 0 0 0 0 23 6 6 0 0 0 0 0 6 84 0 % D
% Glu: 0 0 0 6 67 0 6 6 0 12 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 12 84 0 0 0 0 6 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 6 6 0 0 0 0 0 6 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 6 0 17 0 0 0 0 6 6 0 0 0 % I
% Lys: 0 0 0 6 0 0 0 0 6 84 0 0 0 0 12 % K
% Leu: 0 0 6 84 0 0 0 0 6 0 0 6 84 6 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 % N
% Pro: 0 0 0 0 0 0 0 6 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 6 0 0 0 0 0 6 6 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 6 62 % R
% Ser: 0 0 23 0 0 6 62 0 6 6 89 73 6 0 12 % S
% Thr: 0 0 0 0 0 0 17 0 0 0 0 6 0 0 0 % T
% Val: 6 0 6 0 6 67 0 0 0 0 0 6 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 89 84 0 0 0 6 12 73 0 0 0 0 6 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _