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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CDKL2 All Species: 16.97
Human Site: S391 Identified Species: 31.11
UniProt: Q92772 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92772 NP_003939.1 493 56019 S391 S H N K I V P S T S L K D C S
Chimpanzee Pan troglodytes XP_001153844 566 64313 S387 S H N K I V P S T S L K D C S
Rhesus Macaque Macaca mulatta NP_001129485 570 64691 S391 S H I K I V P S T S L K D C S
Dog Lupus familis XP_535605 561 63942 S392 N N I K T V P S T S L R D C S
Cat Felis silvestris
Mouse Mus musculus Q9QUK0 568 64037 T391 N H K G L A S T S L R D C S N
Rat Rattus norvegicus Q5XIT0 507 57117 T391 S H K G L S S T S L R D C S N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512927 637 71445 F390 H G D V S E N F L P L Q D L K
Chicken Gallus gallus P13863 303 34670 H205 A T K K P L F H G D S E I D Q
Frog Xenopus laevis P35567 302 34487 F204 I A T K K P L F H G D S E I D
Zebra Danio Brachydanio rerio Q6AXJ9 350 40792 K252 E M E P L E L K Y P N L S Y Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P23572 297 34420 T199 C I F A E M A T R K P L F Q G
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784044 926 104004 P420 I S S S S K L P Q H I G G H N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P24100 294 34012 E196 S V G C I F A E M I S Q K P L
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 79.5 84 78.2 N.A. 74.8 81.8 N.A. 38.1 29.8 30.2 39.1 N.A. 27.9 N.A. N.A. 33.5
Protein Similarity: 100 81.8 84.9 82.1 N.A. 80.2 86.9 N.A. 55.7 41.7 43.8 53.5 N.A. 41.7 N.A. N.A. 44.2
P-Site Identity: 100 100 93.3 66.6 N.A. 6.6 13.3 N.A. 13.3 6.6 6.6 0 N.A. 0 N.A. N.A. 0
P-Site Similarity: 100 100 93.3 86.6 N.A. 40 40 N.A. 26.6 26.6 13.3 6.6 N.A. 13.3 N.A. N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. 27.5 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 40.7 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 0 8 0 8 16 0 0 0 0 0 0 0 0 % A
% Cys: 8 0 0 8 0 0 0 0 0 0 0 0 16 31 0 % C
% Asp: 0 0 8 0 0 0 0 0 0 8 8 16 39 8 8 % D
% Glu: 8 0 8 0 8 16 0 8 0 0 0 8 8 0 0 % E
% Phe: 0 0 8 0 0 8 8 16 0 0 0 0 8 0 0 % F
% Gly: 0 8 8 16 0 0 0 0 8 8 0 8 8 0 8 % G
% His: 8 39 0 0 0 0 0 8 8 8 0 0 0 8 0 % H
% Ile: 16 8 16 0 31 0 0 0 0 8 8 0 8 8 0 % I
% Lys: 0 0 24 47 8 8 0 8 0 8 0 24 8 0 8 % K
% Leu: 0 0 0 0 24 8 24 0 8 16 39 16 0 8 8 % L
% Met: 0 8 0 0 0 8 0 0 8 0 0 0 0 0 0 % M
% Asn: 16 8 16 0 0 0 8 0 0 0 8 0 0 0 24 % N
% Pro: 0 0 0 8 8 8 31 8 0 16 8 0 0 8 0 % P
% Gln: 0 0 0 0 0 0 0 0 8 0 0 16 0 8 16 % Q
% Arg: 0 0 0 0 0 0 0 0 8 0 16 8 0 0 0 % R
% Ser: 39 8 8 8 16 8 16 31 16 31 16 8 8 16 31 % S
% Thr: 0 8 8 0 8 0 0 24 31 0 0 0 0 0 0 % T
% Val: 0 8 0 8 0 31 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 8 0 0 0 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _