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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC2
All Species:
53.64
Human Site:
Y337
Identified Species:
84.29
UniProt:
Q92769
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92769
NP_001518.2
488
55364
Y337
P
Y
N
D
Y
F
E
Y
F
G
P
D
F
K
L
Chimpanzee
Pan troglodytes
XP_518700
581
65611
Y430
P
Y
N
D
Y
F
E
Y
F
G
P
D
F
K
L
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532270
481
54585
Y330
P
Y
N
D
Y
F
E
Y
F
G
P
D
F
K
L
Cat
Felis silvestris
Mouse
Mus musculus
P70288
488
55284
Y337
P
Y
N
D
Y
F
E
Y
F
G
P
D
F
K
L
Rat
Rattus norvegicus
Q4QQW4
482
55074
Y336
P
Y
N
D
Y
F
E
Y
F
G
P
D
F
K
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521848
455
51607
Y333
P
Y
N
D
Y
F
E
Y
F
G
P
D
F
K
L
Chicken
Gallus gallus
P56519
488
55134
Y337
P
Y
N
D
Y
F
E
Y
F
G
P
D
F
K
L
Frog
Xenopus laevis
O42227
480
54874
Y336
P
Y
N
D
Y
F
E
Y
F
G
P
D
F
K
L
Zebra Danio
Brachydanio rerio
Q803C3
428
48962
L313
C
W
T
F
E
T
S
L
L
V
E
E
S
I
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q94517
521
58312
Y334
P
Y
N
D
Y
F
E
Y
F
G
P
D
F
K
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O17695
461
52119
Y340
P
Y
N
D
Y
F
E
Y
F
G
P
N
Y
R
L
Sea Urchin
Strong. purpuratus
P56518
576
64060
Y335
P
Y
N
D
Y
F
E
Y
F
G
P
D
F
K
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P56521
513
57528
Y349
P
V
N
E
Y
Y
E
Y
F
G
P
D
Y
T
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FML2
471
52633
Y348
P
Y
N
E
Y
F
E
Y
F
G
P
D
Y
T
L
Baker's Yeast
Sacchar. cerevisiae
P32561
433
48886
V318
G
G
Y
T
M
R
N
V
A
R
T
W
C
F
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
83.9
N.A.
96.5
N.A.
99.3
85.8
N.A.
90.7
98.1
87.6
52.6
N.A.
73.3
N.A.
58.8
69.1
Protein Similarity:
100
83.9
N.A.
97.3
N.A.
99.3
93.6
N.A.
91.1
98.1
94.4
70.6
N.A.
81.9
N.A.
76
78.4
P-Site Identity:
100
100
N.A.
100
N.A.
100
100
N.A.
100
100
100
0
N.A.
100
N.A.
80
100
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
100
100
100
13.3
N.A.
100
N.A.
100
100
Percent
Protein Identity:
N.A.
53.6
N.A.
56.3
53.8
N.A.
Protein Similarity:
N.A.
70.5
N.A.
72.3
69.4
N.A.
P-Site Identity:
N.A.
66.6
N.A.
80
0
N.A.
P-Site Similarity:
N.A.
86.6
N.A.
93.3
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% A
% Cys:
7
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% C
% Asp:
0
0
0
74
0
0
0
0
0
0
0
80
0
0
0
% D
% Glu:
0
0
0
14
7
0
87
0
0
0
7
7
0
0
7
% E
% Phe:
0
0
0
7
0
80
0
0
87
0
0
0
67
7
0
% F
% Gly:
7
7
0
0
0
0
0
0
0
87
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
67
0
% K
% Leu:
0
0
0
0
0
0
0
7
7
0
0
0
0
0
87
% L
% Met:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
87
0
0
0
7
0
0
0
0
7
0
0
0
% N
% Pro:
87
0
0
0
0
0
0
0
0
0
87
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
7
0
0
0
7
0
0
0
7
0
% R
% Ser:
0
0
0
0
0
0
7
0
0
0
0
0
7
0
7
% S
% Thr:
0
0
7
7
0
7
0
0
0
0
7
0
0
14
0
% T
% Val:
0
7
0
0
0
0
0
7
0
7
0
0
0
0
0
% V
% Trp:
0
7
0
0
0
0
0
0
0
0
0
7
0
0
0
% W
% Tyr:
0
80
7
0
87
7
0
87
0
0
0
0
20
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _