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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC2
All Species:
23.64
Human Site:
S79
Identified Species:
37.14
UniProt:
Q92769
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92769
NP_001518.2
488
55364
S79
E
Y
I
K
F
L
R
S
I
R
P
D
N
M
S
Chimpanzee
Pan troglodytes
XP_518700
581
65611
S172
E
Y
I
K
F
L
R
S
I
R
P
D
N
M
S
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532270
481
54585
Y81
R
P
D
N
M
S
E
Y
S
K
Q
M
Q
R
F
Cat
Felis silvestris
Mouse
Mus musculus
P70288
488
55284
S79
E
Y
I
K
F
L
R
S
I
R
P
D
N
M
S
Rat
Rattus norvegicus
Q4QQW4
482
55074
I79
Y
I
K
F
L
R
S
I
R
P
D
N
M
S
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521848
455
51607
N80
L
R
S
I
R
P
D
N
M
S
E
Y
S
K
Q
Chicken
Gallus gallus
P56519
488
55134
S79
E
Y
I
K
F
L
R
S
I
R
P
D
N
M
S
Frog
Xenopus laevis
O42227
480
54874
I79
Y
I
K
F
L
R
S
I
R
P
D
N
M
S
E
Zebra Danio
Brachydanio rerio
Q803C3
428
48962
I67
R
F
H
S
E
D
Y
I
D
F
L
Q
K
V
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q94517
521
58312
N81
L
R
S
I
R
P
D
N
M
S
E
Y
N
K
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O17695
461
52119
S82
E
Y
M
T
F
L
K
S
A
N
P
D
N
L
K
Sea Urchin
Strong. purpuratus
P56518
576
64060
P80
K
F
L
R
T
I
R
P
D
N
M
S
E
Y
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P56521
513
57528
S92
E
Y
I
N
F
L
R
S
V
T
P
E
T
Q
Q
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FML2
471
52633
S88
E
Y
V
D
F
L
A
S
V
S
P
E
S
M
G
Baker's Yeast
Sacchar. cerevisiae
P32561
433
48886
Q72
R
A
K
P
A
T
K
Q
E
M
C
Q
F
H
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
83.9
N.A.
96.5
N.A.
99.3
85.8
N.A.
90.7
98.1
87.6
52.6
N.A.
73.3
N.A.
58.8
69.1
Protein Similarity:
100
83.9
N.A.
97.3
N.A.
99.3
93.6
N.A.
91.1
98.1
94.4
70.6
N.A.
81.9
N.A.
76
78.4
P-Site Identity:
100
100
N.A.
0
N.A.
100
0
N.A.
0
100
0
6.6
N.A.
6.6
N.A.
53.3
6.6
P-Site Similarity:
100
100
N.A.
6.6
N.A.
100
6.6
N.A.
20
100
6.6
20
N.A.
20
N.A.
73.3
46.6
Percent
Protein Identity:
N.A.
53.6
N.A.
56.3
53.8
N.A.
Protein Similarity:
N.A.
70.5
N.A.
72.3
69.4
N.A.
P-Site Identity:
N.A.
53.3
N.A.
46.6
0
N.A.
P-Site Similarity:
N.A.
66.6
N.A.
73.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
0
7
0
7
0
7
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% C
% Asp:
0
0
7
7
0
7
14
0
14
0
14
34
0
0
0
% D
% Glu:
47
0
0
0
7
0
7
0
7
0
14
14
7
0
14
% E
% Phe:
0
14
0
14
47
0
0
0
0
7
0
0
7
0
7
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% G
% His:
0
0
7
0
0
0
0
0
0
0
0
0
0
7
0
% H
% Ile:
0
14
34
14
0
7
0
20
27
0
0
0
0
0
0
% I
% Lys:
7
0
20
27
0
0
14
0
0
7
0
0
7
14
7
% K
% Leu:
14
0
7
0
14
47
0
0
0
0
7
0
0
7
0
% L
% Met:
0
0
7
0
7
0
0
0
14
7
7
7
14
34
0
% M
% Asn:
0
0
0
14
0
0
0
14
0
14
0
14
40
0
0
% N
% Pro:
0
7
0
7
0
14
0
7
0
14
47
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
7
0
0
7
14
7
7
20
% Q
% Arg:
20
14
0
7
14
14
40
0
14
27
0
0
0
7
0
% R
% Ser:
0
0
14
7
0
7
14
47
7
20
0
7
14
14
34
% S
% Thr:
0
0
0
7
7
7
0
0
0
7
0
0
7
0
14
% T
% Val:
0
0
7
0
0
0
0
0
14
0
0
0
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
14
47
0
0
0
0
7
7
0
0
0
14
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _