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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC2
All Species:
33.03
Human Site:
S407
Identified Species:
51.9
UniProt:
Q92769
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92769
NP_001518.2
488
55364
S407
E
D
P
D
K
R
I
S
I
R
A
S
D
K
R
Chimpanzee
Pan troglodytes
XP_518700
581
65611
S500
E
D
P
D
K
R
I
S
I
R
A
S
D
K
R
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532270
481
54585
S400
E
D
P
D
K
R
I
S
I
R
A
S
D
K
R
Cat
Felis silvestris
Mouse
Mus musculus
P70288
488
55284
S407
E
D
P
D
K
R
I
S
I
R
A
S
D
K
R
Rat
Rattus norvegicus
Q4QQW4
482
55074
S406
E
D
P
D
K
R
I
S
I
C
S
S
D
K
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521848
455
51607
H387
A
I
P
E
D
A
V
H
E
D
S
G
D
E
D
Chicken
Gallus gallus
P56519
488
55134
S407
E
D
P
D
K
R
I
S
I
R
A
S
D
K
R
Frog
Xenopus laevis
O42227
480
54874
S406
E
D
P
D
K
R
I
S
I
R
S
S
D
K
R
Zebra Danio
Brachydanio rerio
Q803C3
428
48962
F363
E
Q
I
R
Q
T
V
F
E
N
L
K
M
L
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q94517
521
58312
P404
V
D
K
D
D
R
L
P
Q
S
D
K
D
K
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O17695
461
52119
D391
Q
M
R
P
I
P
E
D
A
L
S
A
L
N
D
Sea Urchin
Strong. purpuratus
P56518
576
64060
S406
E
N
P
D
K
R
I
S
I
M
A
Q
D
K
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P56521
513
57528
S430
D
H
K
A
V
E
E
S
S
R
R
S
I
L
G
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FML2
471
52633
L403
T
P
P
V
N
R
V
L
D
E
P
E
D
D
M
Baker's Yeast
Sacchar. cerevisiae
P32561
433
48886
Y368
F
N
V
N
T
P
E
Y
L
D
K
V
M
T
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
83.9
N.A.
96.5
N.A.
99.3
85.8
N.A.
90.7
98.1
87.6
52.6
N.A.
73.3
N.A.
58.8
69.1
Protein Similarity:
100
83.9
N.A.
97.3
N.A.
99.3
93.6
N.A.
91.1
98.1
94.4
70.6
N.A.
81.9
N.A.
76
78.4
P-Site Identity:
100
100
N.A.
100
N.A.
100
86.6
N.A.
13.3
100
93.3
6.6
N.A.
40
N.A.
0
80
P-Site Similarity:
100
100
N.A.
100
N.A.
100
93.3
N.A.
40
100
100
20
N.A.
46.6
N.A.
20
86.6
Percent
Protein Identity:
N.A.
53.6
N.A.
56.3
53.8
N.A.
Protein Similarity:
N.A.
70.5
N.A.
72.3
69.4
N.A.
P-Site Identity:
N.A.
20
N.A.
20
0
N.A.
P-Site Similarity:
N.A.
26.6
N.A.
26.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
7
0
7
0
0
7
0
40
7
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% C
% Asp:
7
54
0
60
14
0
0
7
7
14
7
0
74
7
14
% D
% Glu:
60
0
0
7
0
7
20
0
14
7
0
7
0
7
0
% E
% Phe:
7
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
7
% G
% His:
0
7
0
0
0
0
0
7
0
0
0
0
0
0
0
% H
% Ile:
0
7
7
0
7
0
54
0
54
0
0
0
7
0
0
% I
% Lys:
0
0
14
0
54
0
0
0
0
0
7
14
0
60
0
% K
% Leu:
0
0
0
0
0
0
7
7
7
7
7
0
7
14
0
% L
% Met:
0
7
0
0
0
0
0
0
0
7
0
0
14
0
7
% M
% Asn:
0
14
0
7
7
0
0
0
0
7
0
0
0
7
14
% N
% Pro:
0
7
67
7
0
14
0
7
0
0
7
0
0
0
0
% P
% Gln:
7
7
0
0
7
0
0
0
7
0
0
7
0
0
0
% Q
% Arg:
0
0
7
7
0
67
0
0
0
47
7
0
0
0
60
% R
% Ser:
0
0
0
0
0
0
0
60
7
7
27
54
0
0
0
% S
% Thr:
7
0
0
0
7
7
0
0
0
0
0
0
0
7
0
% T
% Val:
7
0
7
7
7
0
20
0
0
0
0
7
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _