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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
APPBP2
All Species:
26.97
Human Site:
Y515
Identified Species:
74.17
UniProt:
Q92624
Number Species:
8
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92624
NP_006371.2
585
66853
Y515
E
G
Y
S
G
L
E
Y
D
Y
R
G
L
I
K
Chimpanzee
Pan troglodytes
XP_001136833
723
81168
Y653
E
G
Y
S
G
L
E
Y
D
Y
R
G
L
I
K
Rhesus Macaque
Macaca mulatta
XP_001107544
419
47858
D350
G
Y
S
G
L
E
Y
D
Y
R
G
L
I
K
L
Dog
Lupus familis
XP_537708
585
66904
Y515
E
G
Y
S
G
L
E
Y
D
Y
R
G
L
I
K
Cat
Felis silvestris
Mouse
Mus musculus
Q9DAX9
585
66837
Y515
E
G
Y
S
G
L
E
Y
D
Y
R
G
L
I
K
Rat
Rattus norvegicus
A5HK05
585
66884
Y515
E
G
Y
S
G
L
E
Y
D
Y
R
G
L
I
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001025894
586
66889
Y516
E
G
Y
S
G
L
E
Y
D
Y
R
G
L
I
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572328
686
78525
Y604
N
S
Y
S
G
L
E
Y
D
Y
L
G
L
C
H
Honey Bee
Apis mellifera
XP_395464
569
65671
Y500
R
D
A
E
R
L
Y
Y
R
S
I
G
I
S
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
80.7
71.4
99.4
N.A.
99.1
98.8
N.A.
N.A.
96
N.A.
N.A.
N.A.
38
50.4
N.A.
N.A.
Protein Similarity:
100
80.9
71.6
99.8
N.A.
100
99.8
N.A.
N.A.
98.9
N.A.
N.A.
N.A.
55.2
69.2
N.A.
N.A.
P-Site Identity:
100
100
0
100
N.A.
100
100
N.A.
N.A.
100
N.A.
N.A.
N.A.
66.6
20
N.A.
N.A.
P-Site Similarity:
100
100
6.6
100
N.A.
100
100
N.A.
N.A.
100
N.A.
N.A.
N.A.
66.6
26.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
12
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
12
0
% C
% Asp:
0
12
0
0
0
0
0
12
78
0
0
0
0
0
0
% D
% Glu:
67
0
0
12
0
12
78
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
12
67
0
12
78
0
0
0
0
0
12
89
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
12
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
12
0
23
67
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
12
67
% K
% Leu:
0
0
0
0
12
89
0
0
0
0
12
12
78
0
23
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
12
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
12
0
0
0
12
0
0
0
12
12
67
0
0
0
0
% R
% Ser:
0
12
12
78
0
0
0
0
0
12
0
0
0
12
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
12
78
0
0
0
23
89
12
78
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _