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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TBC1D5
All Species:
10
Human Site:
S443
Identified Species:
20
UniProt:
Q92609
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92609
NP_001127852.1
795
89004
S443
G
A
D
L
M
N
K
S
R
T
N
A
K
G
A
Chimpanzee
Pan troglodytes
XP_001161013
795
89000
S443
G
A
D
L
M
N
K
S
R
T
N
A
K
G
A
Rhesus Macaque
Macaca mulatta
XP_001084887
797
89359
T445
D
L
M
N
K
S
R
T
N
A
K
G
A
P
L
Dog
Lupus familis
XP_542771
803
90799
S442
G
A
D
L
M
N
K
S
R
T
N
A
K
G
A
Cat
Felis silvestris
Mouse
Mus musculus
Q80XQ2
815
91834
K467
S
L
I
N
F
G
R
K
L
I
S
P
A
S
A
Rat
Rattus norvegicus
NP_001128234
805
90863
N459
L
N
I
H
K
V
S
N
S
L
I
N
F
G
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_001235030
780
87954
L437
Y
K
A
R
G
A
D
L
M
N
K
T
R
A
S
Frog
Xenopus laevis
NP_001085083
800
90348
M452
S
K
P
G
S
S
A
M
V
K
V
S
S
S
L
Zebra Danio
Brachydanio rerio
NP_956905
533
61527
E190
F
C
Y
A
R
E
N
E
Q
L
L
Y
K
Q
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_731780
654
74319
M311
L
H
H
Y
L
Q
K
M
E
I
P
L
H
I
F
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_497979
585
67014
R242
T
V
T
E
S
P
K
R
P
I
P
K
E
P
Y
Sea Urchin
Strong. purpuratus
XP_799336
763
86968
L411
M
L
I
K
I
R
E
L
L
L
T
A
E
Y
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
98.2
89.9
N.A.
87.6
87.1
N.A.
N.A.
78.2
69.2
49.8
N.A.
26.4
N.A.
29.6
36.2
Protein Similarity:
100
99.8
99
92.9
N.A.
91.4
91.6
N.A.
N.A.
86
80.5
58.1
N.A.
45.2
N.A.
43.9
56.6
P-Site Identity:
100
100
0
100
N.A.
6.6
6.6
N.A.
N.A.
0
0
6.6
N.A.
6.6
N.A.
6.6
13.3
P-Site Similarity:
100
100
20
100
N.A.
20
13.3
N.A.
N.A.
13.3
13.3
13.3
N.A.
13.3
N.A.
13.3
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
25
9
9
0
9
9
0
0
9
0
34
17
9
42
% A
% Cys:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
0
25
0
0
0
9
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
9
0
9
9
9
9
0
0
0
17
0
0
% E
% Phe:
9
0
0
0
9
0
0
0
0
0
0
0
9
0
9
% F
% Gly:
25
0
0
9
9
9
0
0
0
0
0
9
0
34
9
% G
% His:
0
9
9
9
0
0
0
0
0
0
0
0
9
0
0
% H
% Ile:
0
0
25
0
9
0
0
0
0
25
9
0
0
9
0
% I
% Lys:
0
17
0
9
17
0
42
9
0
9
17
9
34
0
0
% K
% Leu:
17
25
0
25
9
0
0
17
17
25
9
9
0
0
17
% L
% Met:
9
0
9
0
25
0
0
17
9
0
0
0
0
0
0
% M
% Asn:
0
9
0
17
0
25
9
9
9
9
25
9
0
0
0
% N
% Pro:
0
0
9
0
0
9
0
0
9
0
17
9
0
17
0
% P
% Gln:
0
0
0
0
0
9
0
0
9
0
0
0
0
9
0
% Q
% Arg:
0
0
0
9
9
9
17
9
25
0
0
0
9
0
9
% R
% Ser:
17
0
0
0
17
17
9
25
9
0
9
9
9
17
9
% S
% Thr:
9
0
9
0
0
0
0
9
0
25
9
9
0
0
0
% T
% Val:
0
9
0
0
0
9
0
0
9
0
9
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
0
9
9
0
0
0
0
0
0
0
9
0
9
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _