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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HSPH1 All Species: 37.27
Human Site: Y740 Identified Species: 58.57
UniProt: Q92598 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92598 NP_006635.2 858 96865 Y740 F R N K D E K Y N H I D E S E
Chimpanzee Pan troglodytes XP_001142849 1091 122133 Y973 F R N K D E K Y N H I D E S E
Rhesus Macaque Macaca mulatta XP_001106968 840 94362 Y723 F K N K E D Q Y D H L D A A D
Dog Lupus familis XP_534515 1048 117305 Y930 F R N N D E K Y N H I D E S E
Cat Felis silvestris
Mouse Mus musculus Q61699 858 96389 Y741 F R G K D E K Y N H I D E S E
Rat Rattus norvegicus Q66HA8 858 96400 Y741 F R G K D E K Y N H I D E S E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509055 859 95987 Y741 Y R N K D E K Y I H V D A T E
Chicken Gallus gallus NP_001153170 856 96066 Y740 F R N K D E K Y I H I D E M E
Frog Xenopus laevis P02827 647 70897 L550 L E S Y A F N L K S M V E D E
Zebra Danio Brachydanio rerio NP_956151 840 94728 Y725 Y K T K E E Q Y D H L E E A E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VG58 641 70235 V544 R N A L E S Y V F N V K Q S V
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q05036 776 86878 G679 Y E D Y A N G G P T Y A H L D
Sea Urchin Strong. purpuratus Q06068 889 98600 Y758 Y S N G D E K Y S H I E K E D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P32589 693 77348 D595 E Y A P F A S D A E K T K L Q
Red Bread Mold Neurospora crassa O74225 707 78655 M610 E K I R A K L M E V E D W L Y
Conservation
Percent
Protein Identity: 100 78.6 63.5 76.9 N.A. 93.4 92.4 N.A. 84.7 81.4 28.5 61.7 N.A. 27 N.A. 42 51.1
Protein Similarity: 100 78.6 77.9 79.6 N.A. 96.8 96.6 N.A. 92.5 90.7 45.7 77.3 N.A. 45.9 N.A. 58.9 67.9
P-Site Identity: 100 100 40 93.3 N.A. 93.3 93.3 N.A. 66.6 86.6 13.3 40 N.A. 6.6 N.A. 0 46.6
P-Site Similarity: 100 100 93.3 93.3 N.A. 93.3 93.3 N.A. 86.6 86.6 26.6 93.3 N.A. 33.3 N.A. 20 80
Percent
Protein Identity: N.A. N.A. N.A. N.A. 33.5 36.3
Protein Similarity: N.A. N.A. N.A. N.A. 51 53
P-Site Identity: N.A. N.A. N.A. N.A. 0 6.6
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 26.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 14 0 20 7 0 0 7 0 0 7 14 14 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 7 0 54 7 0 7 14 0 0 60 0 7 20 % D
% Glu: 14 14 0 0 20 60 0 0 7 7 7 14 54 7 60 % E
% Phe: 47 0 0 0 7 7 0 0 7 0 0 0 0 0 0 % F
% Gly: 0 0 14 7 0 0 7 7 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 67 0 0 7 0 0 % H
% Ile: 0 0 7 0 0 0 0 0 14 0 47 0 0 0 0 % I
% Lys: 0 20 0 54 0 7 54 0 7 0 7 7 14 0 0 % K
% Leu: 7 0 0 7 0 0 7 7 0 0 14 0 0 20 0 % L
% Met: 0 0 0 0 0 0 0 7 0 0 7 0 0 7 0 % M
% Asn: 0 7 47 7 0 7 7 0 34 7 0 0 0 0 0 % N
% Pro: 0 0 0 7 0 0 0 0 7 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 14 0 0 0 0 0 7 0 7 % Q
% Arg: 7 47 0 7 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 7 7 0 0 7 7 0 7 7 0 0 0 40 0 % S
% Thr: 0 0 7 0 0 0 0 0 0 7 0 7 0 7 0 % T
% Val: 0 0 0 0 0 0 0 7 0 7 14 7 0 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % W
% Tyr: 27 7 0 14 0 0 7 67 0 0 7 0 0 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _