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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HSPH1 All Species: 42.12
Human Site: T282 Identified Species: 66.19
UniProt: Q92598 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92598 NP_006635.2 858 96865 T282 K L M S S N S T D L P L N I E
Chimpanzee Pan troglodytes XP_001142849 1091 122133 T515 K L M S S N S T D L P L N I E
Rhesus Macaque Macaca mulatta XP_001106968 840 94362 S282 K L M S A N A S D L P L S I E
Dog Lupus familis XP_534515 1048 117305 T471 K L M S S N S T D L P L N I E
Cat Felis silvestris
Mouse Mus musculus Q61699 858 96389 T282 K L M S S N S T D L P L N I E
Rat Rattus norvegicus Q66HA8 858 96400 T282 K L M S S N S T D L P L N I E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509055 859 95987 M282 K L M S S N S M D L P L N I E
Chicken Gallus gallus NP_001153170 856 96066 T282 K L M S S N S T D I P L N I E
Frog Xenopus laevis P02827 647 70897 V164 Q A T K D A G V L A G L N I L
Zebra Danio Brachydanio rerio NP_956151 840 94728 S282 K L M S A N S S D L P L N I E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VG58 641 70235 A158 Q R Q A T K D A G H I A G L N
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q05036 776 86878 T284 K Q M S A N Q T P I P L N I E
Sea Urchin Strong. purpuratus Q06068 889 98600 T282 K L M S A N A T L I S M N I E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P32589 693 77348 Y209 V D I G H S S Y T C S I M A F
Red Bread Mold Neurospora crassa O74225 707 78655 T224 G E L S V K S T A C D R H F G
Conservation
Percent
Protein Identity: 100 78.6 63.5 76.9 N.A. 93.4 92.4 N.A. 84.7 81.4 28.5 61.7 N.A. 27 N.A. 42 51.1
Protein Similarity: 100 78.6 77.9 79.6 N.A. 96.8 96.6 N.A. 92.5 90.7 45.7 77.3 N.A. 45.9 N.A. 58.9 67.9
P-Site Identity: 100 100 73.3 100 N.A. 100 100 N.A. 93.3 93.3 20 86.6 N.A. 0 N.A. 66.6 60
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 93.3 100 26.6 100 N.A. 26.6 N.A. 80 86.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 33.5 36.3
Protein Similarity: N.A. N.A. N.A. N.A. 51 53
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 20
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 0 7 27 7 14 7 7 7 0 7 0 7 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 14 0 0 0 0 0 % C
% Asp: 0 7 0 0 7 0 7 0 60 0 7 0 0 0 0 % D
% Glu: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 74 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 % F
% Gly: 7 0 0 7 0 0 7 0 7 0 7 0 7 0 7 % G
% His: 0 0 0 0 7 0 0 0 0 7 0 0 7 0 0 % H
% Ile: 0 0 7 0 0 0 0 0 0 20 7 7 0 80 0 % I
% Lys: 74 0 0 7 0 14 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 67 7 0 0 0 0 0 14 54 0 74 0 7 7 % L
% Met: 0 0 74 0 0 0 0 7 0 0 0 7 7 0 0 % M
% Asn: 0 0 0 0 0 74 0 0 0 0 0 0 74 0 7 % N
% Pro: 0 0 0 0 0 0 0 0 7 0 67 0 0 0 0 % P
% Gln: 14 7 7 0 0 0 7 0 0 0 0 0 0 0 0 % Q
% Arg: 0 7 0 0 0 0 0 0 0 0 0 7 0 0 0 % R
% Ser: 0 0 0 80 47 7 67 14 0 0 14 0 7 0 0 % S
% Thr: 0 0 7 0 7 0 0 60 7 0 0 0 0 0 0 % T
% Val: 7 0 0 0 7 0 0 7 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _