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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMPDL3B
All Species:
14.55
Human Site:
Y395
Identified Species:
29.09
UniProt:
Q92485
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92485
NP_001009568.1
455
50814
Y395
T
L
Q
R
Y
Y
V
Y
N
S
V
S
Y
S
A
Chimpanzee
Pan troglodytes
XP_001151336
455
50854
Y395
T
L
Q
R
Y
Y
V
Y
N
S
V
S
Y
S
A
Rhesus Macaque
Macaca mulatta
XP_001108274
453
51294
A396
Y
G
L
A
K
Q
F
A
I
I
D
S
K
Q
F
Dog
Lupus familis
XP_544464
468
52011
Y407
A
L
Q
R
Y
Y
V
Y
N
S
V
S
Y
D
P
Cat
Felis silvestris
Mouse
Mus musculus
P58242
456
51581
Y395
I
L
Q
R
Y
Y
V
Y
N
S
V
S
Y
N
H
Rat
Rattus norvegicus
Q641Z7
445
49877
L388
Q
P
K
S
L
H
G
L
A
Q
Q
L
A
T
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516772
436
49539
N373
K
Q
F
Q
K
Y
Y
N
Y
V
F
V
S
Y
N
Chicken
Gallus gallus
XP_001232192
454
51318
F390
Y
L
Q
Q
Y
Y
E
F
N
S
V
R
Y
D
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_692822
457
52265
L396
S
L
Q
K
Y
F
E
L
N
S
V
S
Y
D
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_729555
488
55653
N404
F
T
R
Y
H
R
A
N
A
V
R
Y
H
S
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_505620
755
86279
Y397
L
F
K
K
Y
I
D
Y
N
T
A
F
W
N
P
Sea Urchin
Strong. purpuratus
XP_786766
452
51341
A395
Y
L
Y
N
T
V
M
A
S
A
G
E
C
D
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
40.2
76.2
N.A.
75.6
39.3
N.A.
38
61
N.A.
54.2
N.A.
28.6
N.A.
23.8
39.3
Protein Similarity:
100
99.5
58
83.9
N.A.
86.1
58.4
N.A.
55.8
74
N.A.
71.1
N.A.
47.9
N.A.
37
58
P-Site Identity:
100
100
6.6
80
N.A.
80
0
N.A.
6.6
53.3
N.A.
53.3
N.A.
6.6
N.A.
20
6.6
P-Site Similarity:
100
100
6.6
80
N.A.
86.6
20
N.A.
13.3
66.6
N.A.
73.3
N.A.
26.6
N.A.
53.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
9
0
0
9
17
17
9
9
0
9
0
17
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% C
% Asp:
0
0
0
0
0
0
9
0
0
0
9
0
0
34
0
% D
% Glu:
0
0
0
0
0
0
17
0
0
0
0
9
0
0
9
% E
% Phe:
9
9
9
0
0
9
9
9
0
0
9
9
0
0
9
% F
% Gly:
0
9
0
0
0
0
9
0
0
0
9
0
0
0
9
% G
% His:
0
0
0
0
9
9
0
0
0
0
0
0
9
0
9
% H
% Ile:
9
0
0
0
0
9
0
0
9
9
0
0
0
0
9
% I
% Lys:
9
0
17
17
17
0
0
0
0
0
0
0
9
0
0
% K
% Leu:
9
59
9
0
9
0
0
17
0
0
0
9
0
0
17
% L
% Met:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
9
0
0
0
17
59
0
0
0
0
17
9
% N
% Pro:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
17
% P
% Gln:
9
9
50
17
0
9
0
0
0
9
9
0
0
9
0
% Q
% Arg:
0
0
9
34
0
9
0
0
0
0
9
9
0
0
0
% R
% Ser:
9
0
0
9
0
0
0
0
9
50
0
50
9
25
0
% S
% Thr:
17
9
0
0
9
0
0
0
0
9
0
0
0
9
0
% T
% Val:
0
0
0
0
0
9
34
0
0
17
50
9
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% W
% Tyr:
25
0
9
9
59
50
9
42
9
0
0
9
50
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _