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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TBCK
All Species:
27.27
Human Site:
Y593
Identified Species:
50
UniProt:
Q8TEA7
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8TEA7
NP_001156907.1
893
100680
Y593
N
S
H
V
I
Q
E
Y
L
T
V
F
S
Q
M
Chimpanzee
Pan troglodytes
XP_526648
893
100716
Y593
N
S
H
V
I
Q
E
Y
L
T
V
F
S
Q
M
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_545015
893
100744
Y593
N
S
H
V
I
Q
E
Y
L
T
V
F
S
Q
M
Cat
Felis silvestris
Mouse
Mus musculus
Q8BM85
762
86353
A485
A
L
L
G
V
E
G
A
I
H
A
K
Y
D
A
Rat
Rattus norvegicus
NP_001127985
860
96794
L574
I
S
F
H
D
P
E
L
S
N
H
L
N
E
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510722
898
101284
Y598
N
S
H
V
I
Q
E
Y
L
T
V
F
S
Q
M
Chicken
Gallus gallus
Q5F361
893
100434
Y593
N
S
H
V
I
Q
E
Y
L
T
V
F
S
Q
M
Frog
Xenopus laevis
NP_001087131
893
100210
Y593
N
S
H
V
I
Q
E
Y
L
T
V
F
S
Q
M
Zebra Danio
Brachydanio rerio
NP_001074106
893
100952
Y593
N
S
H
V
I
Q
E
Y
L
T
V
F
S
Q
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572197
819
93251
Q542
K
F
I
P
K
Y
L
Q
W
F
F
L
K
D
N
Honey Bee
Apis mellifera
XP_393033
792
90269
I515
F
E
C
L
S
A
F
I
P
K
Y
L
H
K
F
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001199652
877
98431
K598
F
I
P
K
Y
L
Y
K
F
F
M
K
D
N
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32491
506
56739
A229
E
G
A
G
G
S
V
A
K
C
R
L
K
N
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
N.A.
96.7
N.A.
81
90.5
N.A.
90.3
87.1
81.5
76.7
N.A.
43.6
47.5
N.A.
55.2
Protein Similarity:
100
99.7
N.A.
98.8
N.A.
83.5
94.2
N.A.
94.5
92.8
90
87.6
N.A.
58.5
62.7
N.A.
70.8
P-Site Identity:
100
100
N.A.
100
N.A.
0
13.3
N.A.
100
100
100
100
N.A.
0
0
N.A.
0
P-Site Similarity:
100
100
N.A.
100
N.A.
20
33.3
N.A.
100
100
100
100
N.A.
0
13.3
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
32.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
8
0
0
8
0
16
0
0
8
0
0
0
8
% A
% Cys:
0
0
8
0
0
0
0
0
0
8
0
0
0
0
0
% C
% Asp:
0
0
0
0
8
0
0
0
0
0
0
0
8
16
0
% D
% Glu:
8
8
0
0
0
8
62
0
0
0
0
0
0
8
0
% E
% Phe:
16
8
8
0
0
0
8
0
8
16
8
54
0
0
8
% F
% Gly:
0
8
0
16
8
0
8
0
0
0
0
0
0
0
8
% G
% His:
0
0
54
8
0
0
0
0
0
8
8
0
8
0
0
% H
% Ile:
8
8
8
0
54
0
0
8
8
0
0
0
0
0
8
% I
% Lys:
8
0
0
8
8
0
0
8
8
8
0
16
16
8
0
% K
% Leu:
0
8
8
8
0
8
8
8
54
0
0
31
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
54
% M
% Asn:
54
0
0
0
0
0
0
0
0
8
0
0
8
16
8
% N
% Pro:
0
0
8
8
0
8
0
0
8
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
54
0
8
0
0
0
0
0
54
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% R
% Ser:
0
62
0
0
8
8
0
0
8
0
0
0
54
0
8
% S
% Thr:
0
0
0
0
0
0
0
0
0
54
0
0
0
0
0
% T
% Val:
0
0
0
54
8
0
8
0
0
0
54
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
8
8
54
0
0
8
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _