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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FAT3 All Species: 23.94
Human Site: S4541 Identified Species: 43.89
UniProt: Q8TDW7 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8TDW7 NP_001008781.2 4589 505523 S4541 V S L S L H N S R G T S S S D
Chimpanzee Pan troglodytes XP_001136982 4601 507102 S4553 V S L S L H N S R G T S S S D
Rhesus Macaque Macaca mulatta XP_001084587 4609 507875 S4561 V S L S L H N S R G T S S S D
Dog Lupus familis XP_848507 4589 505147 S4541 M S L S L H N S R G T S S S D
Cat Felis silvestris
Mouse Mus musculus Q8BNA6 4555 501992 S4507 V S L S L H N S R G T S S S E
Rat Rattus norvegicus Q8R508 4555 502069 S4507 V S L S L H N S R G T S S S D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508966 4273 469286 L4226 Y K R V S V R L S V A Q P S Y
Chicken Gallus gallus NP_001104793 4557 501888 L4510 P L T L H N S L D A S S S D V
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_998132 4610 506620 T4560 N M S L S L Y T S T A S C S D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VW71 4705 524557 R4657 R M E I K T R R T I S E N S E
Honey Bee Apis mellifera XP_394631 3607 400577 N3560 I T T L E E R N S L L G G A T
Nematode Worm Caenorhab. elegans Q19319 4292 477180 A4245 P P A I P A H A T P L E S V L
Sea Urchin Strong. purpuratus XP_785422 3852 424350 A3805 I S D I S Q D A L S M S M Y T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.6 97.9 95.5 N.A. 91.9 92.3 N.A. 40 86.4 N.A. 50.6 N.A. 36 31.2 26.7 21.7
Protein Similarity: 100 98.8 98.3 98.3 N.A. 96.2 96.4 N.A. 57.6 93.3 N.A. 69.1 N.A. 54.8 46.1 46.9 39.2
P-Site Identity: 100 100 100 93.3 N.A. 93.3 100 N.A. 6.6 13.3 N.A. 20 N.A. 6.6 0 6.6 13.3
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 6.6 33.3 N.A. 26.6 N.A. 26.6 26.6 20 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 0 0 8 0 16 0 8 16 0 0 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % C
% Asp: 0 0 8 0 0 0 8 0 8 0 0 0 0 8 47 % D
% Glu: 0 0 8 0 8 8 0 0 0 0 0 16 0 0 16 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 47 0 8 8 0 0 % G
% His: 0 0 0 0 8 47 8 0 0 0 0 0 0 0 0 % H
% Ile: 16 0 0 24 0 0 0 0 0 8 0 0 0 0 0 % I
% Lys: 0 8 0 0 8 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 8 47 24 47 8 0 16 8 8 16 0 0 0 8 % L
% Met: 8 16 0 0 0 0 0 0 0 0 8 0 8 0 0 % M
% Asn: 8 0 0 0 0 8 47 8 0 0 0 0 8 0 0 % N
% Pro: 16 8 0 0 8 0 0 0 0 8 0 0 8 0 0 % P
% Gln: 0 0 0 0 0 8 0 0 0 0 0 8 0 0 0 % Q
% Arg: 8 0 8 0 0 0 24 8 47 0 0 0 0 0 0 % R
% Ser: 0 54 8 47 24 0 8 47 24 8 16 70 62 70 0 % S
% Thr: 0 8 16 0 0 8 0 8 16 8 47 0 0 0 16 % T
% Val: 39 0 0 8 0 8 0 0 0 8 0 0 0 8 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 0 8 0 0 0 0 0 0 8 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _