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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
KLHDC4
All Species:
4.85
Human Site:
S516
Identified Species:
8.89
UniProt:
Q8TBB5
Number Species:
12
Phosphosite Substitution
Charge Score:
0.42
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8TBB5
NP_060036.2
520
57892
S516
D
E
D
S
G
E
E
S
G
A
E
D
_
_
_
Chimpanzee
Pan troglodytes
XP_001157133
541
60088
G516
D
D
S
G
E
E
S
G
G
G
L
R
R
A
P
Rhesus Macaque
Macaca mulatta
XP_001086874
522
58135
E516
D
E
D
E
D
S
G
E
E
S
G
A
E
D
_
Dog
Lupus familis
XP_546788
667
72888
G625
G
E
S
D
K
E
A
G
A
A
C
S
L
P
A
Cat
Felis silvestris
Mouse
Mus musculus
Q921I2
584
64842
E516
K
D
Q
E
D
S
A
E
E
G
A
D
P
Q
H
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508869
624
70162
E563
E
D
T
E
E
E
S
E
E
D
E
E
E
E
Q
Chicken
Gallus gallus
NP_001025749
579
65046
S517
E
E
S
S
E
E
D
S
E
D
E
G
G
E
E
Frog
Xenopus laevis
NP_001079516
578
65206
E518
E
E
E
E
E
D
S
E
E
S
D
E
D
S
H
Zebra Danio
Brachydanio rerio
NP_001119902
585
65979
E521
E
D
D
E
D
E
E
E
S
D
D
E
S
E
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_648590
509
56333
Honey Bee
Apis mellifera
XP_624296
469
54330
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SDM9
470
51651
Baker's Yeast
Sacchar. cerevisiae
Q08979
651
75415
S551
E
G
D
E
D
E
E
S
E
S
D
D
D
K
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93.3
95.7
63.2
N.A.
72.7
N.A.
N.A.
62.1
69
64.3
63.4
N.A.
41.1
41.5
N.A.
N.A.
Protein Similarity:
100
94.6
97.5
70.9
N.A.
79.4
N.A.
N.A.
72.4
79.2
76.1
74
N.A.
59.6
58.4
N.A.
N.A.
P-Site Identity:
100
20
21.4
20
N.A.
6.6
N.A.
N.A.
13.3
33.3
6.6
20
N.A.
0
0
N.A.
N.A.
P-Site Similarity:
100
26.6
28.5
20
N.A.
13.3
N.A.
N.A.
33.3
53.3
46.6
46.6
N.A.
0
0
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.5
27.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
35.7
41.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
33.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
16
0
8
16
8
8
0
8
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% C
% Asp:
24
31
31
8
31
8
8
0
0
24
24
24
16
8
0
% D
% Glu:
39
39
8
47
31
54
24
39
47
0
24
24
16
24
16
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
8
0
8
8
0
8
16
16
16
8
8
8
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
16
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
8
0
0
0
8
0
0
0
0
0
0
0
0
8
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
8
0
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
8
8
8
% P
% Gln:
0
0
8
0
0
0
0
0
0
0
0
0
0
8
16
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
8
8
0
0
% R
% Ser:
0
0
24
16
0
16
24
24
8
24
0
8
8
8
0
% S
% Thr:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
8
8
16
% _