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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
KLHDC4
All Species:
16.06
Human Site:
S418
Identified Species:
29.44
UniProt:
Q8TBB5
Number Species:
12
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8TBB5
NP_060036.2
520
57892
S418
P
R
S
E
D
E
D
S
L
E
E
A
G
S
P
Chimpanzee
Pan troglodytes
XP_001157133
541
60088
S418
P
R
S
E
D
E
D
S
L
E
E
A
G
S
P
Rhesus Macaque
Macaca mulatta
XP_001086874
522
58135
S418
P
Q
S
E
D
E
D
S
L
E
E
A
G
S
P
Dog
Lupus familis
XP_546788
667
72888
S527
P
Q
S
N
E
E
D
S
P
D
E
V
G
G
P
Cat
Felis silvestris
Mouse
Mus musculus
Q921I2
584
64842
S418
P
S
P
K
A
D
D
S
A
S
E
A
S
S
T
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508869
624
70162
A465
K
S
E
S
E
D
E
A
G
G
E
A
R
G
P
Chicken
Gallus gallus
NP_001025749
579
65046
E419
R
S
E
S
E
E
E
E
E
D
G
A
L
G
P
Frog
Xenopus laevis
NP_001079516
578
65206
E420
E
D
S
V
E
E
E
E
E
E
G
A
R
S
P
Zebra Danio
Brachydanio rerio
NP_001119902
585
65979
E423
E
D
E
E
V
E
E
E
A
A
A
A
A
A
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_648590
509
56333
S412
P
F
V
S
K
I
P
S
L
F
A
K
P
K
P
Honey Bee
Apis mellifera
XP_624296
469
54330
I376
D
G
I
F
T
V
T
I
G
S
T
Q
K
T
T
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SDM9
470
51651
G377
V
F
A
S
A
A
I
G
K
H
I
V
I
F
G
Baker's Yeast
Sacchar. cerevisiae
Q08979
651
75415
N440
E
D
D
S
D
L
D
N
Q
E
D
I
T
I
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93.3
95.7
63.2
N.A.
72.7
N.A.
N.A.
62.1
69
64.3
63.4
N.A.
41.1
41.5
N.A.
N.A.
Protein Similarity:
100
94.6
97.5
70.9
N.A.
79.4
N.A.
N.A.
72.4
79.2
76.1
74
N.A.
59.6
58.4
N.A.
N.A.
P-Site Identity:
100
100
93.3
53.3
N.A.
40
N.A.
N.A.
20
20
40
26.6
N.A.
26.6
0
N.A.
N.A.
P-Site Similarity:
100
100
100
73.3
N.A.
53.3
N.A.
N.A.
46.6
40
53.3
40
N.A.
26.6
6.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.5
27.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
35.7
41.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
16
8
0
8
16
8
16
62
8
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
24
8
0
31
16
47
0
0
16
8
0
0
0
0
% D
% Glu:
24
0
24
31
31
54
31
24
16
39
47
0
0
0
0
% E
% Phe:
0
16
0
8
0
0
0
0
0
8
0
0
0
8
0
% F
% Gly:
0
8
0
0
0
0
0
8
16
8
16
0
31
24
8
% G
% His:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% H
% Ile:
0
0
8
0
0
8
8
8
0
0
8
8
8
8
0
% I
% Lys:
8
0
0
8
8
0
0
0
8
0
0
8
8
8
0
% K
% Leu:
0
0
0
0
0
8
0
0
31
0
0
0
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
8
0
0
0
8
0
0
0
0
0
0
0
% N
% Pro:
47
0
8
0
0
0
8
0
8
0
0
0
8
0
70
% P
% Gln:
0
16
0
0
0
0
0
0
8
0
0
8
0
0
0
% Q
% Arg:
8
16
0
0
0
0
0
0
0
0
0
0
16
0
0
% R
% Ser:
0
24
39
39
0
0
0
47
0
16
0
0
8
39
8
% S
% Thr:
0
0
0
0
8
0
8
0
0
0
8
0
8
8
16
% T
% Val:
8
0
8
8
8
8
0
0
0
0
0
16
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _