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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HMGCLL1 All Species: 15.45
Human Site: Y313 Identified Species: 28.33
UniProt: Q8TB92 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8TB92 NP_001035865.1 370 39514 Y313 S G L G G C P Y A K G A S G N
Chimpanzee Pan troglodytes XP_001166273 325 34328 Q270 L G G C P Y A Q G A S G N L A
Rhesus Macaque Macaca mulatta XP_001105003 444 47056 Y387 S G L G G C P Y A K G A S G N
Dog Lupus familis XP_538973 343 36798 S288 C P Y A K G A S G N V A T E D
Cat Felis silvestris
Mouse Mus musculus Q8JZS7 343 36632 S288 C P Y A K G A S G N V A T E D
Rat Rattus norvegicus P97519 325 34173 K270 L G G C P Y A K G A S G N L A
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P35915 298 31418 Q243 L G G C P Y A Q G A S G N V A
Frog Xenopus laevis NP_001085152 328 34788 Q273 L G G C P Y A Q G A S G N V A
Zebra Danio Brachydanio rerio A8WG57 335 35873 K280 L G G C P F A K G A S G N V S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001196745 313 33056 K258 L G G C P Y A K G A S G N V A
Poplar Tree Populus trichocarpa XP_002308880 293 30640 C238 S V S G L G G C P Y A K G A S
Maize Zea mays NP_001132253 434 44858 Y370 A G L G G C P Y A K G A S G N
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O81027 468 50558 Y403 A G L G G C P Y A K G A S G N
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 61.6 80.6 88.6 N.A. 85.1 61.3 N.A. N.A. 58.6 58.1 64.5 N.A. N.A. N.A. N.A. 55.4
Protein Similarity: 100 74 81 90.2 N.A. 88.6 74.8 N.A. N.A. 69.4 70.5 78.3 N.A. N.A. N.A. N.A. 68.6
P-Site Identity: 100 6.6 100 6.6 N.A. 6.6 6.6 N.A. N.A. 6.6 6.6 6.6 N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: 100 13.3 100 20 N.A. 20 13.3 N.A. N.A. 13.3 13.3 20 N.A. N.A. N.A. N.A. 13.3
Percent
Protein Identity: 50.8 47.9 N.A. 45.7 N.A. N.A.
Protein Similarity: 63.5 61.5 N.A. 59.6 N.A. N.A.
P-Site Identity: 13.3 93.3 N.A. 93.3 N.A. N.A.
P-Site Similarity: 20 100 N.A. 100 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 16 0 0 16 0 0 62 0 31 47 8 47 0 8 39 % A
% Cys: 16 0 0 47 0 31 0 8 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 16 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 16 0 % E
% Phe: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 77 47 39 31 24 8 0 62 0 31 47 8 31 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 16 0 0 24 0 31 0 8 0 0 0 % K
% Leu: 47 0 31 0 8 0 0 0 0 0 0 0 0 16 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 16 0 0 47 0 31 % N
% Pro: 0 16 0 0 47 0 31 0 8 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 24 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 24 0 8 0 0 0 0 16 0 0 47 0 31 0 16 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 16 0 0 % T
% Val: 0 8 0 0 0 0 0 0 0 0 16 0 0 31 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 16 0 0 39 0 31 0 8 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _