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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HMGCLL1 All Species: 4.24
Human Site: Y221 Identified Species: 7.78
UniProt: Q8TB92 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8TB92 NP_001035865.1 370 39514 Y221 S C A L G C P Y E G S I T P Q
Chimpanzee Pan troglodytes XP_001166273 325 34328 I180 G C P Y E G K I S P A K V A E
Rhesus Macaque Macaca mulatta XP_001105003 444 47056 Y295 S C A L G C P Y E G I I T P Q
Dog Lupus familis XP_538973 343 36798 Q198 Y E G N I T P Q K V T E V S K
Cat Felis silvestris
Mouse Mus musculus Q8JZS7 343 36632 Q198 Y E G S I T P Q K V T E V S K
Rat Rattus norvegicus P97519 325 34173 V180 G C P Y E G K V S P A K V A E
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P35915 298 31418 I153 G C P Y E G N I S A A K V A E
Frog Xenopus laevis NP_001085152 328 34788 V183 G C P Y E G K V A P S K V A E
Zebra Danio Brachydanio rerio A8WG57 335 35873 V190 G C P Y E G Q V K P S Q V T K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001196745 313 33056 V168 G C P Y E G A V Q P E A V A K
Poplar Tree Populus trichocarpa XP_002308880 293 30640 V148 S C V V G C P V E G M V S P S
Maize Zea mays NP_001132253 434 44858 V278 S C V V G C P V D G P V P P S
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O81027 468 50558 V311 S C V V G C P V E G P V L P S
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 61.6 80.6 88.6 N.A. 85.1 61.3 N.A. N.A. 58.6 58.1 64.5 N.A. N.A. N.A. N.A. 55.4
Protein Similarity: 100 74 81 90.2 N.A. 88.6 74.8 N.A. N.A. 69.4 70.5 78.3 N.A. N.A. N.A. N.A. 68.6
P-Site Identity: 100 6.6 93.3 6.6 N.A. 6.6 6.6 N.A. N.A. 6.6 13.3 13.3 N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: 100 20 93.3 26.6 N.A. 26.6 20 N.A. N.A. 20 20 26.6 N.A. N.A. N.A. N.A. 20
Percent
Protein Identity: 50.8 47.9 N.A. 45.7 N.A. N.A.
Protein Similarity: 63.5 61.5 N.A. 59.6 N.A. N.A.
P-Site Identity: 53.3 46.6 N.A. 53.3 N.A. N.A.
P-Site Similarity: 73.3 66.6 N.A. 66.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 16 0 0 0 8 0 8 8 24 8 0 39 0 % A
% Cys: 0 85 0 0 0 39 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % D
% Glu: 0 16 0 0 47 0 0 0 31 0 8 16 0 0 31 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 47 0 16 0 39 47 0 0 0 39 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 16 0 0 16 0 0 8 16 0 0 0 % I
% Lys: 0 0 0 0 0 0 24 0 24 0 0 31 0 0 31 % K
% Leu: 0 0 0 16 0 0 0 0 0 0 0 0 8 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % M
% Asn: 0 0 0 8 0 0 8 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 47 0 0 0 54 0 0 39 16 0 8 39 0 % P
% Gln: 0 0 0 0 0 0 8 16 8 0 0 8 0 0 16 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 39 0 0 8 0 0 0 0 24 0 24 0 8 16 24 % S
% Thr: 0 0 0 0 0 16 0 0 0 0 16 0 16 8 0 % T
% Val: 0 0 24 24 0 0 0 54 0 16 0 24 62 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 16 0 0 47 0 0 0 16 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _