KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGCLL1
All Species:
8.18
Human Site:
Y143
Identified Species:
15
UniProt:
Q8TB92
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8TB92
NP_001035865.1
370
39514
Y143
V
M
K
G
I
H
Q
Y
P
G
V
R
Y
P
V
Chimpanzee
Pan troglodytes
XP_001166273
325
34328
N102
I
Q
K
F
P
G
I
N
Y
P
V
L
T
P
N
Rhesus Macaque
Macaca mulatta
XP_001105003
444
47056
Y217
V
M
K
G
I
H
Q
Y
P
G
V
H
Y
P
V
Dog
Lupus familis
XP_538973
343
36798
V120
Y
P
G
V
R
Y
P
V
L
T
P
N
L
Q
G
Cat
Felis silvestris
Mouse
Mus musculus
Q8JZS7
343
36632
V120
Y
P
G
V
R
Y
P
V
L
T
P
N
L
Q
G
Rat
Rattus norvegicus
P97519
325
34173
N102
I
Q
K
F
P
G
I
N
Y
P
V
L
T
P
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P35915
298
31418
S75
I
N
K
L
P
G
V
S
Y
P
V
L
T
P
N
Frog
Xenopus laevis
NP_001085152
328
34788
S105
I
K
K
Y
P
N
I
S
Y
P
V
L
T
P
N
Zebra Danio
Brachydanio rerio
A8WG57
335
35873
R112
I
K
R
S
P
D
V
R
Y
P
V
L
T
P
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001196745
313
33056
S90
I
T
R
R
G
G
V
S
Y
P
V
L
T
P
N
Poplar Tree
Populus trichocarpa
XP_002308880
293
30640
F70
V
M
E
A
I
R
D
F
K
G
A
R
F
P
V
Maize
Zea mays
NP_001132253
434
44858
M200
V
M
E
A
V
R
T
M
G
G
V
R
F
P
V
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O81027
468
50558
L233
V
M
D
A
V
N
T
L
D
G
A
R
L
P
V
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
61.6
80.6
88.6
N.A.
85.1
61.3
N.A.
N.A.
58.6
58.1
64.5
N.A.
N.A.
N.A.
N.A.
55.4
Protein Similarity:
100
74
81
90.2
N.A.
88.6
74.8
N.A.
N.A.
69.4
70.5
78.3
N.A.
N.A.
N.A.
N.A.
68.6
P-Site Identity:
100
20
93.3
0
N.A.
0
20
N.A.
N.A.
20
20
13.3
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
26.6
93.3
6.6
N.A.
6.6
26.6
N.A.
N.A.
26.6
33.3
26.6
N.A.
N.A.
N.A.
N.A.
26.6
Percent
Protein Identity:
50.8
47.9
N.A.
45.7
N.A.
N.A.
Protein Similarity:
63.5
61.5
N.A.
59.6
N.A.
N.A.
P-Site Identity:
46.6
46.6
N.A.
40
N.A.
N.A.
P-Site Similarity:
66.6
66.6
N.A.
53.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
24
0
0
0
0
0
0
16
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
0
0
8
8
0
8
0
0
0
0
0
0
% D
% Glu:
0
0
16
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
16
0
0
0
8
0
0
0
0
16
0
0
% F
% Gly:
0
0
16
16
8
31
0
0
8
39
0
0
0
0
16
% G
% His:
0
0
0
0
0
16
0
0
0
0
0
8
0
0
0
% H
% Ile:
47
0
0
0
24
0
24
0
0
0
0
0
0
0
0
% I
% Lys:
0
16
47
0
0
0
0
0
8
0
0
0
0
0
0
% K
% Leu:
0
0
0
8
0
0
0
8
16
0
0
47
24
0
0
% L
% Met:
0
39
0
0
0
0
0
8
0
0
0
0
0
0
0
% M
% Asn:
0
8
0
0
0
16
0
16
0
0
0
16
0
0
47
% N
% Pro:
0
16
0
0
39
0
16
0
16
47
16
0
0
85
0
% P
% Gln:
0
16
0
0
0
0
16
0
0
0
0
0
0
16
0
% Q
% Arg:
0
0
16
8
16
16
0
8
0
0
0
31
0
0
0
% R
% Ser:
0
0
0
8
0
0
0
24
0
0
0
0
0
0
0
% S
% Thr:
0
8
0
0
0
0
16
0
0
16
0
0
47
0
0
% T
% Val:
39
0
0
16
16
0
24
16
0
0
70
0
0
0
39
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
16
0
0
8
0
16
0
16
47
0
0
0
16
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _