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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGCLL1
All Species:
19.09
Human Site:
S258
Identified Species:
35
UniProt:
Q8TB92
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8TB92
NP_001035865.1
370
39514
S258
I
G
V
G
T
P
G
S
M
K
R
M
L
E
S
Chimpanzee
Pan troglodytes
XP_001166273
325
34328
M217
T
P
G
I
M
K
D
M
L
S
A
V
M
Q
E
Rhesus Macaque
Macaca mulatta
XP_001105003
444
47056
S332
I
G
V
G
T
P
G
S
M
K
R
M
L
E
S
Dog
Lupus familis
XP_538973
343
36798
S235
S
M
K
R
M
L
E
S
V
M
K
E
I
P
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8JZS7
343
36632
S235
S
M
K
M
M
L
E
S
V
M
K
E
I
P
P
Rat
Rattus norvegicus
P97519
325
34173
M217
T
P
G
L
M
K
D
M
L
T
A
V
L
H
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P35915
298
31418
M190
T
P
G
S
M
K
E
M
L
A
A
V
M
K
E
Frog
Xenopus laevis
NP_001085152
328
34788
M220
T
P
G
G
M
R
D
M
L
S
A
V
L
D
V
Zebra Danio
Brachydanio rerio
A8WG57
335
35873
M227
T
A
G
S
M
A
E
M
L
S
D
V
L
T
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001196745
313
33056
L205
T
P
G
Q
M
Q
V
L
L
E
T
V
L
E
T
Poplar Tree
Populus trichocarpa
XP_002308880
293
30640
T185
I
G
V
G
T
P
G
T
V
I
P
M
L
E
A
Maize
Zea mays
NP_001132253
434
44858
T315
I
G
V
G
T
P
G
T
V
V
P
M
L
E
A
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O81027
468
50558
S348
I
G
I
G
T
P
G
S
V
V
P
M
L
E
A
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
61.6
80.6
88.6
N.A.
85.1
61.3
N.A.
N.A.
58.6
58.1
64.5
N.A.
N.A.
N.A.
N.A.
55.4
Protein Similarity:
100
74
81
90.2
N.A.
88.6
74.8
N.A.
N.A.
69.4
70.5
78.3
N.A.
N.A.
N.A.
N.A.
68.6
P-Site Identity:
100
0
100
13.3
N.A.
6.6
6.6
N.A.
N.A.
0
13.3
6.6
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
26.6
100
33.3
N.A.
26.6
20
N.A.
N.A.
26.6
33.3
20
N.A.
N.A.
N.A.
N.A.
40
Percent
Protein Identity:
50.8
47.9
N.A.
45.7
N.A.
N.A.
Protein Similarity:
63.5
61.5
N.A.
59.6
N.A.
N.A.
P-Site Identity:
66.6
66.6
N.A.
66.6
N.A.
N.A.
P-Site Similarity:
86.6
86.6
N.A.
86.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
8
0
0
0
8
31
0
0
0
24
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
24
0
0
0
8
0
0
8
0
% D
% Glu:
0
0
0
0
0
0
31
0
0
8
0
16
0
47
31
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
39
47
47
0
0
39
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
39
0
8
8
0
0
0
0
0
8
0
0
16
0
0
% I
% Lys:
0
0
16
0
0
24
0
0
0
16
16
0
0
8
0
% K
% Leu:
0
0
0
8
0
16
0
8
47
0
0
0
70
0
0
% L
% Met:
0
16
0
8
62
0
0
39
16
16
0
39
16
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
39
0
0
0
39
0
0
0
0
24
0
0
16
8
% P
% Gln:
0
0
0
8
0
8
0
0
0
0
0
0
0
8
0
% Q
% Arg:
0
0
0
8
0
8
0
0
0
0
16
0
0
0
0
% R
% Ser:
16
0
0
16
0
0
0
39
0
24
0
0
0
0
24
% S
% Thr:
47
0
0
0
39
0
0
16
0
8
8
0
0
8
8
% T
% Val:
0
0
31
0
0
0
8
0
39
16
0
47
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _