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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DEPDC6
All Species:
18.18
Human Site:
S252
Identified Species:
40
UniProt:
Q8TB45
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8TB45
NP_073620.2
409
46294
S252
P
F
C
L
R
K
Q
S
H
D
N
R
K
S
T
Chimpanzee
Pan troglodytes
XP_519926
207
22794
K55
K
Q
S
H
D
N
R
K
S
T
S
F
M
S
V
Rhesus Macaque
Macaca mulatta
XP_001097652
409
46319
S252
P
F
C
L
R
K
Q
S
H
D
N
R
K
S
T
Dog
Lupus familis
XP_539149
408
46002
S251
P
F
C
L
R
K
Q
S
H
D
N
R
K
S
T
Cat
Felis silvestris
Mouse
Mus musculus
Q570Y9
409
46101
S252
P
F
C
L
R
K
Q
S
H
D
S
R
K
S
T
Rat
Rattus norvegicus
XP_001066889
409
46208
S252
P
F
C
L
R
K
Q
S
H
D
N
R
K
S
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506508
409
46681
H253
P
F
C
L
R
K
L
H
P
E
Q
G
N
T
S
Chicken
Gallus gallus
XP_418463
397
45473
N240
P
F
C
L
R
K
Q
N
H
D
N
R
K
H
T
Frog
Xenopus laevis
NP_001088972
406
45836
F237
Q
E
S
P
D
S
P
F
C
L
R
K
L
S
S
Zebra Danio
Brachydanio rerio
NP_001070788
348
39828
Y196
F
V
D
G
G
L
L
Y
Q
F
R
M
N
F
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001189237
370
41450
M210
S
G
S
G
E
A
A
M
M
A
S
L
T
I
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
50.6
99.5
98.5
N.A.
96
97.8
N.A.
63.8
86.3
53
67.9
N.A.
N.A.
N.A.
N.A.
32.5
Protein Similarity:
100
50.6
99.5
98.5
N.A.
97.5
98.2
N.A.
78.4
90.2
67.2
75
N.A.
N.A.
N.A.
N.A.
48.9
P-Site Identity:
100
6.6
100
100
N.A.
93.3
100
N.A.
40
86.6
6.6
0
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
20
100
100
N.A.
100
100
N.A.
60
93.3
20
0
N.A.
N.A.
N.A.
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
10
10
0
0
10
0
0
0
0
0
% A
% Cys:
0
0
64
0
0
0
0
0
10
0
0
0
0
0
0
% C
% Asp:
0
0
10
0
19
0
0
0
0
55
0
0
0
0
0
% D
% Glu:
0
10
0
0
10
0
0
0
0
10
0
0
0
0
0
% E
% Phe:
10
64
0
0
0
0
0
10
0
10
0
10
0
10
0
% F
% Gly:
0
10
0
19
10
0
0
0
0
0
0
10
0
0
0
% G
% His:
0
0
0
10
0
0
0
10
55
0
0
0
0
10
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% I
% Lys:
10
0
0
0
0
64
0
10
0
0
0
10
55
0
0
% K
% Leu:
0
0
0
64
0
10
19
0
0
10
0
10
10
0
0
% L
% Met:
0
0
0
0
0
0
0
10
10
0
0
10
10
0
0
% M
% Asn:
0
0
0
0
0
10
0
10
0
0
46
0
19
0
0
% N
% Pro:
64
0
0
10
0
0
10
0
10
0
0
0
0
0
10
% P
% Gln:
10
10
0
0
0
0
55
0
10
0
10
0
0
0
0
% Q
% Arg:
0
0
0
0
64
0
10
0
0
0
19
55
0
0
10
% R
% Ser:
10
0
28
0
0
10
0
46
10
0
28
0
0
64
19
% S
% Thr:
0
0
0
0
0
0
0
0
0
10
0
0
10
10
55
% T
% Val:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _