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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
APPL2
All Species:
22.73
Human Site:
T124
Identified Species:
62.5
UniProt:
Q8NEU8
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NEU8
NP_060641.2
664
74493
T124
Q
F
R
E
K
D
L
T
E
V
S
T
L
K
D
Chimpanzee
Pan troglodytes
XP_001160746
665
74599
T124
Q
F
R
E
K
D
L
T
E
V
S
T
L
K
D
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_538418
662
74179
T124
Q
F
R
E
K
D
L
T
E
V
S
T
L
K
D
Cat
Felis silvestris
Mouse
Mus musculus
Q8K3G9
662
73835
T124
Q
F
R
E
K
D
L
T
E
V
S
T
L
K
D
Rat
Rattus norvegicus
Q5FVC7
770
87211
R118
N
F
V
K
E
D
L
R
K
F
K
D
A
K
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508102
695
77800
T157
Q
F
R
E
K
D
L
T
E
V
S
T
L
R
D
Chicken
Gallus gallus
Q5ZK62
781
88436
K118
T
F
V
K
E
D
I
K
K
F
K
D
A
K
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001121547
662
74440
T125
Q
F
R
E
K
D
L
T
E
I
S
T
L
K
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784602
759
84098
A124
R
F
M
N
S
D
I
A
E
I
M
S
M
R
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
N.A.
93.8
N.A.
92.4
20.2
N.A.
84.3
20.4
N.A.
69.7
N.A.
N.A.
N.A.
N.A.
33
Protein Similarity:
100
99.5
N.A.
97.2
N.A.
95.9
41.5
N.A.
89.5
40.7
N.A.
84.4
N.A.
N.A.
N.A.
N.A.
52.4
P-Site Identity:
100
100
N.A.
100
N.A.
100
26.6
N.A.
93.3
20
N.A.
86.6
N.A.
N.A.
N.A.
N.A.
20
P-Site Similarity:
100
100
N.A.
100
N.A.
100
46.6
N.A.
100
46.6
N.A.
100
N.A.
N.A.
N.A.
N.A.
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
12
0
0
0
0
23
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
100
0
0
0
0
0
23
0
0
56
% D
% Glu:
0
0
0
67
23
0
0
0
78
0
0
0
0
0
23
% E
% Phe:
0
100
0
0
0
0
0
0
0
23
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
23
0
0
23
0
0
0
0
0
% I
% Lys:
0
0
0
23
67
0
0
12
23
0
23
0
0
78
23
% K
% Leu:
0
0
0
0
0
0
78
0
0
0
0
0
67
0
0
% L
% Met:
0
0
12
0
0
0
0
0
0
0
12
0
12
0
0
% M
% Asn:
12
0
0
12
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
67
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
12
0
67
0
0
0
0
12
0
0
0
0
0
23
0
% R
% Ser:
0
0
0
0
12
0
0
0
0
0
67
12
0
0
0
% S
% Thr:
12
0
0
0
0
0
0
67
0
0
0
67
0
0
0
% T
% Val:
0
0
23
0
0
0
0
0
0
56
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _