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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
APPL2
All Species:
6.06
Human Site:
S481
Identified Species:
16.67
UniProt:
Q8NEU8
Number Species:
8
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NEU8
NP_060641.2
664
74493
S481
F
G
E
T
E
D
E
S
F
P
E
A
E
D
S
Chimpanzee
Pan troglodytes
XP_001160746
665
74599
S481
F
G
E
T
E
D
E
S
F
P
E
A
E
D
S
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_538418
662
74179
P481
E
T
E
D
E
T
F
P
E
A
E
D
S
L
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8K3G9
662
73835
P481
E
T
E
D
G
S
F
P
E
A
E
D
S
L
L
Rat
Rattus norvegicus
Q5FVC7
770
87211
E469
E
L
L
K
L
M
C
E
L
G
N
D
V
I
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508102
695
77800
S514
E
S
E
D
E
K
Q
S
N
E
E
D
T
L
L
Chicken
Gallus gallus
Q5ZK62
781
88436
P590
S
A
N
S
L
Y
E
P
E
G
E
K
Q
E
S
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001121547
662
74440
D480
G
E
T
E
E
D
D
D
E
S
D
T
H
D
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784602
759
84098
P485
P
S
L
T
K
A
S
P
T
Q
R
D
I
P
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
N.A.
93.8
N.A.
92.4
20.2
N.A.
84.3
20.4
N.A.
69.7
N.A.
N.A.
N.A.
N.A.
33
Protein Similarity:
100
99.5
N.A.
97.2
N.A.
95.9
41.5
N.A.
89.5
40.7
N.A.
84.4
N.A.
N.A.
N.A.
N.A.
52.4
P-Site Identity:
100
100
N.A.
20
N.A.
13.3
0
N.A.
26.6
20
N.A.
26.6
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
N.A.
20
N.A.
13.3
6.6
N.A.
33.3
40
N.A.
40
N.A.
N.A.
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
12
0
0
0
12
0
0
0
23
0
23
0
0
0
% A
% Cys:
0
0
0
0
0
0
12
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
34
0
34
12
12
0
0
12
56
0
34
0
% D
% Glu:
45
12
56
12
56
0
34
12
45
12
67
0
23
12
0
% E
% Phe:
23
0
0
0
0
0
23
0
23
0
0
0
0
0
0
% F
% Gly:
12
23
0
0
12
0
0
0
0
23
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
12
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
12
12
0
% I
% Lys:
0
0
0
12
12
12
0
0
0
0
0
12
0
0
0
% K
% Leu:
0
12
23
0
23
0
0
0
12
0
0
0
0
34
34
% L
% Met:
0
0
0
0
0
12
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
12
0
0
0
0
0
12
0
12
0
0
0
12
% N
% Pro:
12
0
0
0
0
0
0
45
0
23
0
0
0
12
12
% P
% Gln:
0
0
0
0
0
0
12
0
0
12
0
0
12
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
12
0
0
0
0
% R
% Ser:
12
23
0
12
0
12
12
34
0
12
0
0
23
0
45
% S
% Thr:
0
23
12
34
0
12
0
0
12
0
0
12
12
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
12
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
12
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _