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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK9
All Species:
10.3
Human Site:
S666
Identified Species:
37.78
UniProt:
Q8NBP7
Number Species:
6
Phosphosite Substitution
Charge Score:
-0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NBP7
NP_777596.2
692
74372
S666
R
D
V
S
T
T
G
S
T
S
E
E
A
V
T
Chimpanzee
Pan troglodytes
A8T644
692
74315
S666
R
D
V
S
T
A
G
S
T
S
E
E
A
V
A
Rhesus Macaque
Macaca mulatta
A8T666
692
74509
S666
R
D
V
S
T
T
G
S
T
S
K
E
A
V
A
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q80W65
694
74805
R669
H
D
T
A
R
A
D
R
T
S
G
E
A
T
V
Rat
Rattus norvegicus
P59996
691
74690
R665
R
D
A
G
R
A
D
R
T
S
E
E
A
T
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001088613
676
74160
S647
I
D
D
T
C
V
V
S
N
P
T
G
G
K
G
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001190946
626
64435
T601
P
G
P
I
T
S
T
T
N
A
L
F
V
K
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
96.3
N.A.
N.A.
76.8
77
N.A.
N.A.
N.A.
59
N.A.
N.A.
N.A.
N.A.
N.A.
26.8
Protein Similarity:
100
99.4
97.5
N.A.
N.A.
83.8
83
N.A.
N.A.
N.A.
74.7
N.A.
N.A.
N.A.
N.A.
N.A.
40.3
P-Site Identity:
100
86.6
86.6
N.A.
N.A.
33.3
46.6
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
86.6
93.3
N.A.
N.A.
40
46.6
N.A.
N.A.
N.A.
20
N.A.
N.A.
N.A.
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
15
15
0
43
0
0
0
15
0
0
72
0
29
% A
% Cys:
0
0
0
0
15
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
86
15
0
0
0
29
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
43
72
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
15
0
0
15
% F
% Gly:
0
15
0
15
0
0
43
0
0
0
15
15
15
0
15
% G
% His:
15
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
15
0
0
15
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
15
0
0
29
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
15
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
29
0
0
0
0
0
0
% N
% Pro:
15
0
15
0
0
0
0
0
0
15
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
58
0
0
0
29
0
0
29
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
43
0
15
0
58
0
72
0
0
0
0
0
% S
% Thr:
0
0
15
15
58
29
15
15
72
0
15
0
0
29
15
% T
% Val:
0
0
43
0
0
15
15
0
0
0
0
0
15
43
29
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _