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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK9
All Species:
22.42
Human Site:
S381
Identified Species:
82.22
UniProt:
Q8NBP7
Number Species:
6
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NBP7
NP_777596.2
692
74372
S381
D
C
S
T
C
F
V
S
Q
S
G
T
S
Q
A
Chimpanzee
Pan troglodytes
A8T644
692
74315
S381
D
C
S
T
C
F
V
S
Q
S
G
T
S
Q
A
Rhesus Macaque
Macaca mulatta
A8T666
692
74509
S381
D
C
S
T
C
F
V
S
R
S
G
T
S
Q
A
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q80W65
694
74805
S384
D
C
S
T
C
F
M
S
Q
S
G
T
S
Q
A
Rat
Rattus norvegicus
P59996
691
74690
S380
D
C
S
T
C
Y
M
S
Q
S
G
T
S
Q
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001088613
676
74160
S372
D
C
S
T
C
F
T
S
K
S
G
T
S
Q
A
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001190946
626
64435
G349
L
L
T
K
S
I
S
G
A
V
S
D
I
G
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
96.3
N.A.
N.A.
76.8
77
N.A.
N.A.
N.A.
59
N.A.
N.A.
N.A.
N.A.
N.A.
26.8
Protein Similarity:
100
99.4
97.5
N.A.
N.A.
83.8
83
N.A.
N.A.
N.A.
74.7
N.A.
N.A.
N.A.
N.A.
N.A.
40.3
P-Site Identity:
100
100
93.3
N.A.
N.A.
93.3
86.6
N.A.
N.A.
N.A.
86.6
N.A.
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
100
100
N.A.
N.A.
100
100
N.A.
N.A.
N.A.
93.3
N.A.
N.A.
N.A.
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
15
0
0
0
0
0
86
% A
% Cys:
0
86
0
0
86
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
86
0
0
0
0
0
0
0
0
0
0
15
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
72
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
15
0
0
86
0
0
15
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
15
0
0
0
0
0
0
15
0
0
% I
% Lys:
0
0
0
15
0
0
0
0
15
0
0
0
0
0
0
% K
% Leu:
15
15
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
29
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
58
0
0
0
0
86
0
% Q
% Arg:
0
0
0
0
0
0
0
0
15
0
0
0
0
0
0
% R
% Ser:
0
0
86
0
15
0
15
86
0
86
15
0
86
0
15
% S
% Thr:
0
0
15
86
0
0
15
0
0
0
0
86
0
0
0
% T
% Val:
0
0
0
0
0
0
43
0
0
15
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
15
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _