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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PCSK9 All Species: 20.91
Human Site: S249 Identified Species: 76.67
UniProt: Q8NBP7 Number Species: 6
    Phosphosite Substitution
    Charge Score: 0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8NBP7 NP_777596.2 692 74372 S249 A K G A S M R S L R V L N C Q
Chimpanzee Pan troglodytes A8T644 692 74315 S249 A K G A S M R S L R V L N C Q
Rhesus Macaque Macaca mulatta A8T666 692 74509 S249 A K G A G L R S L R V L N C Q
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q80W65 694 74805 S252 A K G T S L H S L R V L N C Q
Rat Rattus norvegicus P59996 691 74690 S248 A K G T S L H S L R V L N C Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis NP_001088613 676 74160 S240 A K G V N V R S L R V L N C Q
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001190946 626 64435 D229 G G A S T T V D D A I L V M I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.9 96.3 N.A. N.A. 76.8 77 N.A. N.A. N.A. 59 N.A. N.A. N.A. N.A. N.A. 26.8
Protein Similarity: 100 99.4 97.5 N.A. N.A. 83.8 83 N.A. N.A. N.A. 74.7 N.A. N.A. N.A. N.A. N.A. 40.3
P-Site Identity: 100 100 86.6 N.A. N.A. 80 80 N.A. N.A. N.A. 80 N.A. N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: 100 100 93.3 N.A. N.A. 86.6 86.6 N.A. N.A. N.A. 93.3 N.A. N.A. N.A. N.A. N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 86 0 15 43 0 0 0 0 0 15 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 86 0 % C
% Asp: 0 0 0 0 0 0 0 15 15 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 15 15 86 0 15 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 29 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 15 0 0 0 15 % I
% Lys: 0 86 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 43 0 0 86 0 0 100 0 0 0 % L
% Met: 0 0 0 0 0 29 0 0 0 0 0 0 0 15 0 % M
% Asn: 0 0 0 0 15 0 0 0 0 0 0 0 86 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 86 % Q
% Arg: 0 0 0 0 0 0 58 0 0 86 0 0 0 0 0 % R
% Ser: 0 0 0 15 58 0 0 86 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 29 15 15 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 15 0 15 15 0 0 0 86 0 15 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _