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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRPF38A
All Species:
25.45
Human Site:
S270
Identified Species:
46.67
UniProt:
Q8NAV1
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NAV1
NP_116253.2
312
37477
S270
P
R
R
H
R
S
R
S
R
D
R
R
H
R
S
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001111695
312
37444
S270
P
R
R
H
R
S
R
S
R
D
R
R
H
R
S
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q4FK66
312
37418
S270
P
R
R
H
R
S
R
S
R
D
R
R
H
R
S
Rat
Rattus norvegicus
Q6AXY7
542
63914
S428
K
K
H
S
R
S
R
S
R
E
R
K
H
R
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_001234245
312
37442
S270
P
R
R
H
R
S
R
S
R
E
R
R
H
R
S
Frog
Xenopus laevis
Q4FZQ6
312
37276
S270
P
R
R
H
R
S
R
S
R
E
R
R
H
R
S
Zebra Danio
Brachydanio rerio
Q6DHU4
313
37532
S270
K
S
P
R
R
H
R
S
R
S
R
E
R
R
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_610463
330
40069
R270
T
H
N
E
D
Y
D
R
R
Q
N
N
G
R
H
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23121
312
35023
S269
A
D
N
R
K
S
R
S
P
S
R
S
P
K
K
Sea Urchin
Strong. purpuratus
XP_781290
318
36969
R270
Q
S
I
P
G
G
R
R
D
I
F
C
R
K
T
Poplar Tree
Populus trichocarpa
XP_002319497
297
35725
H256
D
R
G
R
R
R
S
H
S
R
S
R
S
R
S
Maize
Zea mays
NP_001151258
389
46781
D270
R
E
R
D
R
N
R
D
R
D
R
D
R
H
R
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_565937
355
43154
R290
R
E
R
D
R
R
D
R
A
R
R
R
S
R
S
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
99.6
N.A.
N.A.
98.7
23.6
N.A.
N.A.
97.7
91.6
88.5
N.A.
53.6
N.A.
20.5
51.2
Protein Similarity:
100
N.A.
99.6
N.A.
N.A.
99
35.6
N.A.
N.A.
99
96.7
96.1
N.A.
67.5
N.A.
33.9
64.4
P-Site Identity:
100
N.A.
100
N.A.
N.A.
100
60
N.A.
N.A.
93.3
93.3
40
N.A.
13.3
N.A.
26.6
6.6
P-Site Similarity:
100
N.A.
100
N.A.
N.A.
100
80
N.A.
N.A.
100
100
40
N.A.
13.3
N.A.
40
20
Percent
Protein Identity:
54.1
48.3
N.A.
47.3
N.A.
N.A.
Protein Similarity:
66.9
58.6
N.A.
62.5
N.A.
N.A.
P-Site Identity:
33.3
40
N.A.
40
N.A.
N.A.
P-Site Similarity:
33.3
46.6
N.A.
40
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% C
% Asp:
8
8
0
16
8
0
16
8
8
31
0
8
0
0
0
% D
% Glu:
0
16
0
8
0
0
0
0
0
24
0
8
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% F
% Gly:
0
0
8
0
8
8
0
0
0
0
0
0
8
0
0
% G
% His:
0
8
8
39
0
8
0
8
0
0
0
0
47
8
16
% H
% Ile:
0
0
8
0
0
0
0
0
0
8
0
0
0
0
0
% I
% Lys:
16
8
0
0
8
0
0
0
0
0
0
8
0
16
8
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
16
0
0
8
0
0
0
0
8
8
0
0
0
% N
% Pro:
39
0
8
8
0
0
0
0
8
0
0
0
8
0
0
% P
% Gln:
8
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% Q
% Arg:
16
47
54
24
77
16
77
24
70
16
77
54
24
77
8
% R
% Ser:
0
16
0
8
0
54
8
62
8
16
8
8
16
0
62
% S
% Thr:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _