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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRPF38A
All Species:
19.09
Human Site:
S250
Identified Species:
35
UniProt:
Q8NAV1
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NAV1
NP_116253.2
312
37477
S250
S
R
S
P
K
R
R
S
P
S
P
R
R
E
R
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001111695
312
37444
S250
S
R
S
P
K
R
R
S
P
S
P
R
R
E
R
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q4FK66
312
37418
S250
S
R
S
P
K
R
R
S
P
S
P
R
R
E
R
Rat
Rattus norvegicus
Q6AXY7
542
63914
E408
K
K
H
K
E
D
K
E
D
R
R
H
R
D
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_001234245
312
37442
S250
S
R
S
P
K
R
R
S
P
S
P
R
R
E
R
Frog
Xenopus laevis
Q4FZQ6
312
37276
P250
R
S
P
K
R
R
S
P
S
P
P
R
R
E
R
Zebra Danio
Brachydanio rerio
Q6DHU4
313
37532
S250
S
P
K
R
R
S
P
S
P
R
R
E
R
D
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_610463
330
40069
D250
D
Y
Y
D
E
L
E
D
Y
D
R
Q
R
N
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23121
312
35023
S249
P
K
R
S
R
R
E
S
K
S
K
S
R
S
R
Sea Urchin
Strong. purpuratus
XP_781290
318
36969
V250
R
D
I
F
W
T
N
V
H
F
T
V
D
S
T
Poplar Tree
Populus trichocarpa
XP_002319497
297
35725
R236
G
H
D
R
E
R
E
R
E
R
E
G
R
E
R
Maize
Zea mays
NP_001151258
389
46781
D250
R
D
R
D
Y
D
R
D
Y
G
R
G
R
E
R
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_565937
355
43154
Y270
R
E
R
D
R
D
H
Y
R
E
R
D
R
D
R
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
99.6
N.A.
N.A.
98.7
23.6
N.A.
N.A.
97.7
91.6
88.5
N.A.
53.6
N.A.
20.5
51.2
Protein Similarity:
100
N.A.
99.6
N.A.
N.A.
99
35.6
N.A.
N.A.
99
96.7
96.1
N.A.
67.5
N.A.
33.9
64.4
P-Site Identity:
100
N.A.
100
N.A.
N.A.
100
6.6
N.A.
N.A.
100
40
33.3
N.A.
13.3
N.A.
33.3
0
P-Site Similarity:
100
N.A.
100
N.A.
N.A.
100
33.3
N.A.
N.A.
100
46.6
46.6
N.A.
26.6
N.A.
46.6
0
Percent
Protein Identity:
54.1
48.3
N.A.
47.3
N.A.
N.A.
Protein Similarity:
66.9
58.6
N.A.
62.5
N.A.
N.A.
P-Site Identity:
26.6
26.6
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
33.3
26.6
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
16
8
24
0
24
0
16
8
8
0
8
8
24
8
% D
% Glu:
0
8
0
0
24
0
24
8
8
8
8
8
0
54
0
% E
% Phe:
0
0
0
8
0
0
0
0
0
8
0
0
0
0
0
% F
% Gly:
8
0
0
0
0
0
0
0
0
8
0
16
0
0
0
% G
% His:
0
8
8
0
0
0
8
0
8
0
0
8
0
0
0
% H
% Ile:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
8
16
8
16
31
0
8
0
8
0
8
0
0
0
0
% K
% Leu:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
8
0
0
0
0
0
0
8
0
% N
% Pro:
8
8
8
31
0
0
8
8
39
8
39
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% Q
% Arg:
31
31
24
16
31
54
39
8
8
24
39
39
93
0
85
% R
% Ser:
39
8
31
8
0
8
8
47
8
39
0
8
0
16
0
% S
% Thr:
0
0
0
0
0
8
0
0
0
0
8
0
0
0
8
% T
% Val:
0
0
0
0
0
0
0
8
0
0
0
8
0
0
0
% V
% Trp:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
8
0
8
0
0
8
16
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _