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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CSNK1A1L All Species: 32.42
Human Site: Y175 Identified Species: 50.95
UniProt: Q8N752 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8N752 NP_660204.1 337 39086 Y175 R T R Q H I P Y R E D K H L I
Chimpanzee Pan troglodytes XP_522662 337 39019 Y175 R T R Q H I P Y R E D K H L I
Rhesus Macaque Macaca mulatta XP_001085343 337 38964 Y175 R T R Q H I P Y R E D K H L I
Dog Lupus familis XP_867638 336 38749 Y175 R T R Q H I P Y R E D K N L T
Cat Felis silvestris
Mouse Mus musculus Q9JMK2 416 47304 F248 C K G Y P S E F S T Y L N F C
Rat Rattus norvegicus P97633 325 37477 N167 L A K K Y R D N R T R Q H I P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P67962 337 38882 Y175 R T R Q H I P Y R E D K N L T
Frog Xenopus laevis Q5BP74 415 47421 F248 C K G Y P S E F A T Y L N F C
Zebra Danio Brachydanio rerio Q7T2E3 403 46225 F206 L G Y V L M Y F N L G S L P W
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P54367 337 39516 Y178 H T R H H I V Y R E D K N L T
Honey Bee Apis mellifera XP_393612 350 40282 Y179 R T R M H I M Y R E D K N L T
Nematode Worm Caenorhab. elegans P42168 341 39018 Y174 R T R T H I P Y R E D K N L T
Sea Urchin Strong. purpuratus XP_786391 348 40003 Y189 R S K Q H I Q Y R E D K N L T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P42158 450 50928 F206 L G Y I L M Y F L K G S L P W
Baker's Yeast Sacchar. cerevisiae P29295 494 57322 E309 K Q R D L L I E K G D L N A N
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 97.9 90.5 N.A. 54.5 88.1 N.A. N.A. 90.5 53.9 56.5 N.A. 70.6 76.2 75.3 74.1
Protein Similarity: 100 99.6 99.4 94.3 N.A. 66.1 91 N.A. N.A. 94.6 66 68.2 N.A. 81.3 84 82.1 84.2
P-Site Identity: 100 100 100 86.6 N.A. 0 13.3 N.A. N.A. 86.6 0 0 N.A. 66.6 73.3 80 66.6
P-Site Similarity: 100 100 100 93.3 N.A. 13.3 46.6 N.A. N.A. 93.3 13.3 13.3 N.A. 73.3 80 86.6 86.6
Percent
Protein Identity: N.A. N.A. N.A. 48.6 39.8 N.A.
Protein Similarity: N.A. N.A. N.A. 61.7 52.8 N.A.
P-Site Identity: N.A. N.A. N.A. 0 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 0 0 0 0 0 0 7 0 0 0 0 7 0 % A
% Cys: 14 0 0 0 0 0 0 0 0 0 0 0 0 0 14 % C
% Asp: 0 0 0 7 0 0 7 0 0 0 67 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 14 7 0 60 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 27 0 0 0 0 0 14 0 % F
% Gly: 0 14 14 0 0 0 0 0 0 7 14 0 0 0 0 % G
% His: 7 0 0 7 60 0 0 0 0 0 0 0 27 0 0 % H
% Ile: 0 0 0 7 0 60 7 0 0 0 0 0 0 7 20 % I
% Lys: 7 14 14 7 0 0 0 0 7 7 0 60 0 0 0 % K
% Leu: 20 0 0 0 20 7 0 0 7 7 0 20 14 60 0 % L
% Met: 0 0 0 7 0 14 7 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 7 7 0 0 0 60 0 7 % N
% Pro: 0 0 0 0 14 0 40 0 0 0 0 0 0 14 7 % P
% Gln: 0 7 0 40 0 0 7 0 0 0 0 7 0 0 0 % Q
% Arg: 54 0 60 0 0 7 0 0 67 0 7 0 0 0 0 % R
% Ser: 0 7 0 0 0 14 0 0 7 0 0 14 0 0 0 % S
% Thr: 0 54 0 7 0 0 0 0 0 20 0 0 0 0 40 % T
% Val: 0 0 0 7 0 0 7 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 14 % W
% Tyr: 0 0 14 14 7 0 14 60 0 0 14 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _