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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SH2D3C
All Species:
27.27
Human Site:
Y221
Identified Species:
66.67
UniProt:
Q8N5H7
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8N5H7
NP_001136004.1
860
94411
Y221
D
L
R
S
H
A
W
Y
H
G
R
I
P
R
E
Chimpanzee
Pan troglodytes
XP_001150131
860
94334
Y221
D
L
R
S
H
A
W
Y
H
G
R
I
P
R
E
Rhesus Macaque
Macaca mulatta
XP_001094266
860
94696
Y221
D
L
R
S
H
A
W
Y
H
G
R
I
P
R
E
Dog
Lupus familis
XP_548447
859
94321
Y219
D
L
R
S
H
A
W
Y
H
G
R
I
P
R
E
Cat
Felis silvestris
Mouse
Mus musculus
Q9QZS8
854
94304
Y216
D
L
R
S
H
A
W
Y
H
G
R
I
P
R
E
Rat
Rattus norvegicus
NP_001102049
853
93948
Y216
D
L
R
S
H
A
W
Y
H
G
R
I
P
R
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520958
765
83358
V156
L
T
S
L
G
D
Y
V
L
T
C
R
W
H
H
Chicken
Gallus gallus
XP_422334
1050
117784
Y384
D
L
R
S
H
A
W
Y
H
G
R
I
P
R
Q
Frog
Xenopus laevis
Q6INP9
806
92220
F197
W
K
N
L
S
Q
H
F
K
I
N
K
V
V
I
Zebra Danio
Brachydanio rerio
XP_687225
678
75267
R69
W
Y
H
G
H
I
P
R
E
A
S
E
T
L
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
97
90.2
N.A.
86.1
86.1
N.A.
61.9
33.8
40.5
48.7
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.8
97.7
93.4
N.A.
90.4
90.2
N.A.
70.1
51
57.3
61
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
0
93.3
0
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
6.6
100
6.6
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
70
0
0
0
10
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% C
% Asp:
70
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
10
0
0
10
0
0
60
% E
% Phe:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
10
10
0
0
0
0
70
0
0
0
0
0
% G
% His:
0
0
10
0
80
0
10
0
70
0
0
0
0
10
10
% H
% Ile:
0
0
0
0
0
10
0
0
0
10
0
70
0
0
10
% I
% Lys:
0
10
0
0
0
0
0
0
10
0
0
10
0
0
0
% K
% Leu:
10
70
0
20
0
0
0
0
10
0
0
0
0
10
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
10
0
0
0
0
0
0
0
10
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
10
0
0
0
0
0
70
0
0
% P
% Gln:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
10
% Q
% Arg:
0
0
70
0
0
0
0
10
0
0
70
10
0
70
0
% R
% Ser:
0
0
10
70
10
0
0
0
0
0
10
0
0
0
0
% S
% Thr:
0
10
0
0
0
0
0
0
0
10
0
0
10
0
0
% T
% Val:
0
0
0
0
0
0
0
10
0
0
0
0
10
10
10
% V
% Trp:
20
0
0
0
0
0
70
0
0
0
0
0
10
0
0
% W
% Tyr:
0
10
0
0
0
0
10
70
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _