KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SH2D3C
All Species:
17.27
Human Site:
T474
Identified Species:
42.22
UniProt:
Q8N5H7
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8N5H7
NP_001136004.1
860
94411
T474
P
H
T
S
P
S
H
T
L
G
K
A
S
P
S
Chimpanzee
Pan troglodytes
XP_001150131
860
94334
T474
P
H
T
S
P
S
H
T
L
G
K
A
S
P
S
Rhesus Macaque
Macaca mulatta
XP_001094266
860
94696
T474
P
H
T
S
P
S
H
T
L
C
K
T
S
P
S
Dog
Lupus familis
XP_548447
859
94321
T473
P
Y
A
S
P
S
H
T
L
C
K
A
S
P
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9QZS8
854
94304
T469
P
H
A
S
P
S
H
T
L
C
K
A
S
P
S
Rat
Rattus norvegicus
NP_001102049
853
93948
L469
H
A
S
P
S
H
T
L
C
K
A
S
P
S
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520958
765
83358
S402
Y
C
Q
L
H
P
P
S
P
G
G
R
E
R
A
Chicken
Gallus gallus
XP_422334
1050
117784
K637
K
P
P
P
K
P
S
K
A
T
L
L
K
T
T
Frog
Xenopus laevis
Q6INP9
806
92220
H443
D
C
A
W
S
D
S
H
S
S
H
N
S
Y
I
Zebra Danio
Brachydanio rerio
XP_687225
678
75267
L315
H
G
Y
Q
S
E
S
L
E
Q
G
G
S
Y
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
97
90.2
N.A.
86.1
86.1
N.A.
61.9
33.8
40.5
48.7
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.8
97.7
93.4
N.A.
90.4
90.2
N.A.
70.1
51
57.3
61
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
86.6
80
N.A.
86.6
0
N.A.
6.6
0
6.6
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
86.6
86.6
N.A.
86.6
13.3
N.A.
20
6.6
6.6
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
30
0
0
0
0
0
10
0
10
40
0
0
10
% A
% Cys:
0
20
0
0
0
0
0
0
10
30
0
0
0
0
10
% C
% Asp:
10
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
10
0
0
10
0
0
0
10
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
10
0
0
0
0
0
0
0
30
20
10
0
0
0
% G
% His:
20
40
0
0
10
10
50
10
0
0
10
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% I
% Lys:
10
0
0
0
10
0
0
10
0
10
50
0
10
0
0
% K
% Leu:
0
0
0
10
0
0
0
20
50
0
10
10
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% N
% Pro:
50
10
10
20
50
20
10
0
10
0
0
0
10
50
10
% P
% Gln:
0
0
10
10
0
0
0
0
0
10
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
10
0
10
0
% R
% Ser:
0
0
10
50
30
50
30
10
10
10
0
10
70
10
50
% S
% Thr:
0
0
30
0
0
0
10
50
0
10
0
10
0
10
10
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
10
10
0
0
0
0
0
0
0
0
0
0
20
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _