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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
D2HGDH
All Species:
28.79
Human Site:
T240
Identified Species:
45.24
UniProt:
Q8N465
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8N465
NP_689996.4
521
56416
T240
G
T
V
L
D
C
L
T
S
L
R
K
D
N
T
Chimpanzee
Pan troglodytes
XP_001162772
466
50496
Y216
G
G
L
R
F
L
R
Y
G
S
L
H
G
T
V
Rhesus Macaque
Macaca mulatta
XP_001094865
519
56150
T238
G
T
I
L
D
C
L
T
S
L
R
K
D
N
T
Dog
Lupus familis
XP_852029
541
59008
S260
G
T
V
L
N
C
L
S
T
L
R
K
D
N
T
Cat
Felis silvestris
Mouse
Mus musculus
Q8CIM3
535
58556
T254
G
T
I
L
N
C
L
T
S
L
R
K
D
N
T
Rat
Rattus norvegicus
P84850
535
58786
T254
G
T
I
L
N
C
L
T
S
L
R
K
D
N
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422664
541
59236
A260
G
T
V
L
D
C
L
A
S
L
R
K
D
N
T
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
A1L258
533
58696
A251
G
H
V
L
N
C
L
A
T
L
R
K
D
N
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V778
631
70803
S303
G
T
L
E
R
E
C
S
A
P
R
V
S
C
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O45218
597
66541
C278
K
G
I
I
Q
K
Q
C
Q
V
P
R
M
S
S
Sea Urchin
Strong. purpuratus
XP_783292
557
61383
T275
G
R
I
V
D
C
L
T
S
L
S
K
D
N
T
Poplar Tree
Populus trichocarpa
XP_002310828
530
58306
G246
G
D
V
L
D
M
L
G
T
L
R
K
D
N
T
Maize
Zea mays
NP_001141496
562
61260
T278
G
T
I
L
D
M
L
T
T
L
R
K
D
N
T
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O23240
559
61427
G274
G
N
V
L
D
M
L
G
T
L
R
K
D
N
T
Baker's Yeast
Sacchar. cerevisiae
P46681
530
59250
H242
G
Q
I
V
N
S
M
H
S
M
R
K
D
N
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85
95.5
78.9
N.A.
79.4
79.6
N.A.
N.A.
68.7
N.A.
61.7
N.A.
21.2
N.A.
20.4
53.5
Protein Similarity:
100
86.9
97.1
86.1
N.A.
86.7
87.2
N.A.
N.A.
81.1
N.A.
76.3
N.A.
37
N.A.
38.3
67.8
P-Site Identity:
100
6.6
93.3
80
N.A.
86.6
86.6
N.A.
N.A.
93.3
N.A.
73.3
N.A.
20
N.A.
0
73.3
P-Site Similarity:
100
13.3
100
100
N.A.
100
100
N.A.
N.A.
93.3
N.A.
86.6
N.A.
40
N.A.
40
86.6
Percent
Protein Identity:
52.2
50.8
N.A.
50.8
50.3
N.A.
Protein Similarity:
68.6
65.8
N.A.
65.6
66.6
N.A.
P-Site Identity:
73.3
80
N.A.
73.3
46.6
N.A.
P-Site Similarity:
80
93.3
N.A.
80
80
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
14
7
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
54
7
7
0
0
0
0
0
7
0
% C
% Asp:
0
7
0
0
47
0
0
0
0
0
0
0
80
0
0
% D
% Glu:
0
0
0
7
0
7
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
94
14
0
0
0
0
0
14
7
0
0
0
7
0
7
% G
% His:
0
7
0
0
0
0
0
7
0
0
0
7
0
0
0
% H
% Ile:
0
0
47
7
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
7
0
0
0
0
7
0
0
0
0
0
80
0
0
0
% K
% Leu:
0
0
14
67
0
7
74
0
0
74
7
0
0
0
0
% L
% Met:
0
0
0
0
0
20
7
0
0
7
0
0
7
0
0
% M
% Asn:
0
7
0
0
34
0
0
0
0
0
0
0
0
80
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
7
7
0
0
0
0
% P
% Gln:
0
7
0
0
7
0
7
0
7
0
0
0
0
0
0
% Q
% Arg:
0
7
0
7
7
0
7
0
0
0
80
7
0
0
0
% R
% Ser:
0
0
0
0
0
7
0
14
47
7
7
0
7
7
7
% S
% Thr:
0
54
0
0
0
0
0
40
34
0
0
0
0
7
80
% T
% Val:
0
0
40
14
0
0
0
0
0
7
0
7
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _