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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
D2HGDH
All Species:
48.79
Human Site:
S473
Identified Species:
76.67
UniProt:
Q8N465
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8N465
NP_689996.4
521
56416
S473
A
G
Q
Q
G
S
V
S
A
E
H
G
V
G
F
Chimpanzee
Pan troglodytes
XP_001162772
466
50496
K427
A
R
L
G
P
H
A
K
H
V
V
G
Y
G
H
Rhesus Macaque
Macaca mulatta
XP_001094865
519
56150
S471
A
R
Q
Q
G
S
V
S
A
E
H
G
V
G
F
Dog
Lupus familis
XP_852029
541
59008
S493
A
G
Q
R
G
S
V
S
A
E
H
G
L
G
F
Cat
Felis silvestris
Mouse
Mus musculus
Q8CIM3
535
58556
S487
A
E
Q
R
G
S
V
S
A
E
H
G
L
G
F
Rat
Rattus norvegicus
P84850
535
58786
S487
A
E
Q
R
G
S
V
S
A
E
H
G
L
G
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422664
541
59236
S493
A
R
C
N
G
S
I
S
A
E
H
G
L
G
F
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
A1L258
533
58696
S484
S
Q
W
K
G
S
I
S
A
E
H
G
L
G
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V778
631
70803
S565
L
S
C
G
G
S
L
S
H
H
H
G
V
G
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O45218
597
66541
S543
I
A
C
G
G
S
I
S
H
H
H
G
V
G
K
Sea Urchin
Strong. purpuratus
XP_783292
557
61383
S508
S
E
R
R
G
S
V
S
A
E
H
G
L
G
F
Poplar Tree
Populus trichocarpa
XP_002310828
530
58306
S478
S
K
H
R
G
S
I
S
A
E
H
G
L
G
L
Maize
Zea mays
NP_001141496
562
61260
S513
S
A
Q
R
G
S
I
S
A
E
H
G
L
G
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O23240
559
61427
S508
S
K
H
R
G
S
I
S
A
E
H
G
L
G
V
Baker's Yeast
Sacchar. cerevisiae
P46681
530
59250
S486
S
S
K
H
G
S
V
S
A
E
H
G
L
G
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85
95.5
78.9
N.A.
79.4
79.6
N.A.
N.A.
68.7
N.A.
61.7
N.A.
21.2
N.A.
20.4
53.5
Protein Similarity:
100
86.9
97.1
86.1
N.A.
86.7
87.2
N.A.
N.A.
81.1
N.A.
76.3
N.A.
37
N.A.
38.3
67.8
P-Site Identity:
100
20
93.3
86.6
N.A.
80
80
N.A.
N.A.
66.6
N.A.
53.3
N.A.
46.6
N.A.
46.6
66.6
P-Site Similarity:
100
20
93.3
100
N.A.
93.3
93.3
N.A.
N.A.
80
N.A.
80
N.A.
53.3
N.A.
53.3
93.3
Percent
Protein Identity:
52.2
50.8
N.A.
50.8
50.3
N.A.
Protein Similarity:
68.6
65.8
N.A.
65.6
66.6
N.A.
P-Site Identity:
53.3
60
N.A.
53.3
66.6
N.A.
P-Site Similarity:
80
86.6
N.A.
80
86.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
47
14
0
0
0
0
7
0
80
0
0
0
0
0
0
% A
% Cys:
0
0
20
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
20
0
0
0
0
0
0
0
80
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
54
% F
% Gly:
0
14
0
20
94
0
0
0
0
0
0
100
0
100
0
% G
% His:
0
0
14
7
0
7
0
0
20
14
94
0
0
0
7
% H
% Ile:
7
0
0
0
0
0
40
0
0
0
0
0
0
0
0
% I
% Lys:
0
14
7
7
0
0
0
7
0
0
0
0
0
0
14
% K
% Leu:
7
0
7
0
0
0
7
0
0
0
0
0
67
0
20
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
7
40
14
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
20
7
47
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
40
14
0
0
0
94
0
94
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
47
0
0
7
7
0
27
0
7
% V
% Trp:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _